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Journal articles
Highly potent naphthofuran-based retinoic acid receptor agonists.
Abstract : A collection of arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
https://www.hal.inserm.fr/inserm-00384552
Contributor : Maité Peney <>
Submitted on : Friday, May 15, 2009 - 2:23:49 PM
Last modification on : Tuesday, May 26, 2020 - 11:50:03 AM
Contributor : Maité Peney <>
Submitted on : Friday, May 15, 2009 - 2:23:49 PM
Last modification on : Tuesday, May 26, 2020 - 11:50:03 AM