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Journal articles
Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line.
Abstract : Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
Cited literature [14 references]
https://www.hal.inserm.fr/inserm-00383790
Contributor : Jean-Paul Issartel <>
Submitted on : Friday, July 31, 2009 - 9:35:29 AM
Last modification on : Friday, November 6, 2020 - 3:45:30 AM
Long-term archiving on: : Thursday, June 10, 2010 - 9:21:33 PM
Contributor : Jean-Paul Issartel <>
Submitted on : Friday, July 31, 2009 - 9:35:29 AM
Last modification on : Friday, November 6, 2020 - 3:45:30 AM
Long-term archiving on: : Thursday, June 10, 2010 - 9:21:33 PM
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