Abstract : Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
http://www.hal.inserm.fr/inserm-00383790
Contributeur : Jean-Paul Issartel
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Soumis le : vendredi 31 juillet 2009 - 09:35:29
Dernière modification le : mercredi 25 juillet 2018 - 10:52:02
Document(s) archivé(s) le : jeudi 10 juin 2010 - 21:21:33
Nadine Platet, Jean-François Mayol, François Berger, Francis Hérodin, Didier Wion. Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line.. FEBS Letters, Wiley, 2007, 581 (7), pp.1435-40. 〈10.1016/j.febslet.2007.02.071〉. 〈inserm-00383790〉
