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Rheological characterization of self-hardening hydrogel for tissue engineering applications: gel Point determination and Viscoelastic properties

Abstract : Silated hydroxypropylmethylcellulose (Si-HPMC) is a modified biopolymer used in biomaterial's domain. A hydroxypropylmethylcellulose (HPMC) was functionalised with silane groups. The macromolecular solution of Si-HPMC (pH 12.9) generates an elastic state at physiological pH (~7.4). In this work we present the gel formation of Si-HPMC resulting from the condensation of silanol groups. The crosslinked hydrogel was characterized using rheological techniques. With the scalar percolation model the gelation time was determined as a function of Si-HPMC concentration at 37 °C.
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https://www.hal.inserm.fr/inserm-00383359
Contributor : Ahmed Fatimi <>
Submitted on : Wednesday, May 13, 2009 - 4:46:14 AM
Last modification on : Saturday, May 30, 2020 - 2:11:14 PM
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Ahmed Fatimi, Monique Axelos, Jean-François Tassin, Pierre Weiss. Rheological characterization of self-hardening hydrogel for tissue engineering applications: gel Point determination and Viscoelastic properties. Macromolecular Symposia, Wiley-VCH Verlag, 2008, 266 (1), pp.12-16. ⟨10.1002/masy.200850603⟩. ⟨inserm-00383359⟩

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