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Les enjeux du préanalytique dans l’analyse du transcriptome et du proteome sanguins Application à la recherche clinique: l’expérience du GOELAMS [Stakes of pre-analytical parameters in blood transcriptomic and proteomic analysis. Application to clinical research: the GOELAMS trial]

Abstract : Numerous parameters related to the patients and the conditions of the sample collection can affect the properties of a biological sample. The pre-analytical parameters are especially important to deal with in the setting of multicenter clinical trials. Here, we report the preliminary results of a trial conducted by the cooperative group GOELAMS (Groupe Ouest-Est des Leucémies aiguës et Autres Maladies du Sang) to define the pre-analytical parameters that affect the proteomic analysis of serum samples in patients with B-cell non Hodgkin lymphoma included in clinical trials.
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https://www.hal.inserm.fr/inserm-00382769
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Submitted on : Tuesday, May 12, 2009 - 10:48:09 AM
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Céline Pangault, Marie Arlotto, François Berger, John de Vos, Marie-Christine Béné, et al.. Les enjeux du préanalytique dans l’analyse du transcriptome et du proteome sanguins Application à la recherche clinique: l’expérience du GOELAMS [Stakes of pre-analytical parameters in blood transcriptomic and proteomic analysis. Application to clinical research: the GOELAMS trial]. médecine/sciences, EDP Sciences, 2007, 23 Spec No 1, pp.13-7. ⟨10.1051/medsci/2007231s13⟩. ⟨inserm-00382769⟩

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