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Correlation between the anatomical and functional human subthalamic nucleus.

Abstract : This work addresses the spatial correlation between the anatomical and functional human subthalamic nucleus (STN). The anatomical STN (A-STN), derived from the Schaltenbrand-Wahren brain atlas, is histology based. The functional STN (F-STN) is probabilistic, constructed from neuroelectrophysiological and neuroimaging data of 184 Parkinson's disease patients. The A-STN and F-STN are placed in the same space and compared in terms of mutual relative overlapping of anatomy with function. The F-STN and A-STN correlate well for medium and high probabilities of the F-STN. For probability p >or= 0.3, >95% of F-STN is inside the A-STN, and for p >or= 0.5, the complete F-STN is inside the A-STN for each left and right STN. Therefore, the F-STN for p = 0.5 can potentially be used for identification of the STN in neuroimages.
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https://www.hal.inserm.fr/inserm-00382760
Contributor : Jean-Paul Issartel <>
Submitted on : Monday, May 11, 2009 - 11:49:03 AM
Last modification on : Tuesday, May 12, 2009 - 10:25:00 AM

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Wieslaw Nowinski, A. Thirunavuukarasuu, Jimin Liu, Alim-Louis Benabid. Correlation between the anatomical and functional human subthalamic nucleus.. Stereotactic and Functional Neurosurgery, Karger, 2007, 85 (2-3), pp.88-93. ⟨10.1159/000097924⟩. ⟨inserm-00382760⟩

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