C. A. Alper, A. M. Johnson, A. G. Birtch, and F. D. Moore, Human C'3: Evidence for the Liver as the Primary Site of Synthesis, Science, vol.163, issue.3864, pp.286-288, 1969.
DOI : 10.1126/science.163.3864.286

L. Einstein, P. J. Hansen, M. Ballow, A. E. Davis, I. et al., Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans., Journal of Clinical Investigation, vol.60, issue.5, pp.963-969, 1977.
DOI : 10.1172/JCI108876

Q. Peng, K. Li, H. Patel, S. H. Sacks, and W. Zhou, Dendritic Cell Synthesis of C3 Is Required for Full T Cell Activation and Development of a Th1 Phenotype, The Journal of Immunology, vol.176, issue.6, pp.3330-3341, 2006.
DOI : 10.4049/jimmunol.176.6.3330

E. Reis, D. A. Falcão, and L. Isaac, Clinical Aspects and Molecular Basis of Primary Deficiencies of Complement Component C3 and its Regulatory Proteins Factor I and Factor H, Scandinavian Journal of Immunology, vol.31, issue.3, pp.155-168, 2006.
DOI : 10.1016/S0162-3109(99)00021-1

B. A. Pussell, E. Bourke, M. Nayef, S. Morris, and D. K. Peters, COMPLEMENT DEFICIENCY AND NEPHRITIS A Report of a Family, The Lancet, vol.315, issue.8167, pp.675-677, 1980.
DOI : 10.1016/S0140-6736(80)91169-1

J. Yates, T. Sepp, B. K. Matharu, J. C. Khan, D. A. Thurlby et al., Complement C3 Variant and the Risk of Age-Related Macular Degeneration, New England Journal of Medicine, vol.357, issue.6, pp.553-561, 2007.
DOI : 10.1056/NEJMoa072618

E. C. Miller, M. K. Liszewski, R. Gupta, R. Hauhart, V. Fremeaux-bacchi et al., Mutations of C3 in atypical hemolytic uremic syndrome (aHUS), FASEB J, vol.22, pp.673-679, 2008.

D. Costa, X. J. , M. A. Brockman, E. Alicot, M. Ma et al., Humoral response to herpes simplex virus is complement-dependent, Proc. Natl. Acad. Sci. USA, pp.12708-12712, 1999.
DOI : 10.1073/pnas.96.22.12708

M. B. Fischer, M. Ma, S. Goerg, X. Zhou, J. Xia et al., Regulation of the B cell response to T-dependent antigens by classical pathway complement, J. Immunol, vol.157, pp.549-556, 1996.

M. B. Fischer, S. Goerg, L. Shen, A. P. Prodeus, C. C. Goodnow et al., Dependence of Germinal Center B Cells on Expression of CD21/CD35 for Survival, Science, vol.280, issue.5363, pp.582-585, 1998.
DOI : 10.1126/science.280.5363.582

H. Molina, V. M. Holers, B. Li, Y. Fung, S. Mariathasan et al., Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2., Proc. Natl. Acad. Sci. USA, pp.3357-3361, 1996.
DOI : 10.1073/pnas.93.8.3357

R. Guinamard, M. Okigaki, J. Schlessinger, and J. V. Ravetch, Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response, Nat. Immunol, vol.1, pp.31-36, 2000.

D. T. Fearon and R. H. Carter, The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity, Annual Review of Immunology, vol.13, issue.1, pp.127-149, 1995.
DOI : 10.1146/annurev.iy.13.040195.001015

D. T. Fearon and M. C. Carroll, Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex, Annual Review of Immunology, vol.18, issue.1, pp.393-422, 2000.
DOI : 10.1146/annurev.immunol.18.1.393

Y. Fang, C. Xu, Y. Fu, V. M. Holers, and H. Molina, Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response, J. Immunol, vol.160, pp.5273-5279, 1998.

M. C. Carroll, The Role of Complement in B Cell Activation and Tolerance, Adv. Immunol, vol.74, pp.61-88, 2000.
DOI : 10.1016/S0065-2776(08)60908-6

P. W. Dempsey and D. T. Fearon, Complement: instructing the acquired immune system through the CD21/CD19 complex, Research in Immunology, vol.147, issue.2, pp.71-75, 1996.
DOI : 10.1016/0923-2494(96)87176-8

M. Villiers, C. L. Villiers, A. Laharie, and P. N. Marche, Amplification of the antibody response by C3b complexed to antigen through an ester link, Molecular Immunology, vol.35, issue.6-7, pp.3647-3652, 1999.
DOI : 10.1016/S0161-5890(98)90840-9

M. Villiers, C. L. Villiers, A. Laharie, and P. N. Marche, Different stimulating effects of complement C3b and complete Freund's adjuvant on antibody response, Immunopharmacology, vol.42, issue.1-3, pp.151-157, 1999.
DOI : 10.1016/S0162-3109(99)00017-X

M. Villiers, P. N. Marche, and C. L. Villiers, Improvement of long-lasting response and antibody affinity by the complexation of antigen with complement C3b, International Immunology, vol.15, issue.1, pp.91-95, 2003.
DOI : 10.1093/intimm/dxg014

T. M. Ross, Y. Xu, R. A. Bright, and H. L. Robinson, C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge, Nature Immunology, vol.1, issue.2, pp.127-131, 2000.
DOI : 10.1038/77802

W. Zhou, H. Patel, K. Li, Q. Peng, M. Villiers et al., Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells, Blood, vol.107, issue.6, pp.2461-2469, 2006.
DOI : 10.1182/blood-2005-08-3144

URL : https://hal.archives-ouvertes.fr/inserm-00267056

Q. Peng, K. Li, K. Anderson, C. A. Farrar, B. Lu et al., Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction, Blood, vol.111, issue.4, pp.2452-2461, 2008.
DOI : 10.1182/blood-2007-06-095018

M. Kopf, A. Abel, M. Gallimore, M. F. Carroll, and . Bachmann, Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection, Nature Medicine, vol.8, issue.4, pp.373-378, 2002.
DOI : 10.1038/nm0402-373

M. Suresh, H. Molina, M. S. Salvato, D. Mastellos, J. D. Lambris et al., Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection, The Journal of Immunology, vol.170, issue.2, pp.788-794, 2003.
DOI : 10.4049/jimmunol.170.2.788

M. G. Colomb, D. Ponard, and C. Drouet, Methods employing complement, In Methods of Immunological Analysis, vol.1, pp.536-549, 1993.

A. Salihi, A. , J. Ripoche, L. Pruvost, and M. Fontaine, Purification of complement components by hydrophobic affinity chromatography on phenyl-Sepharose, FEBS Letters, vol.20, issue.1, pp.238-242, 1982.
DOI : 10.1016/0014-5793(82)81342-2

P. Devaux, D. Christiansen, M. Fontaine, and D. Gerlier, Control of C3b and C5b deposition by CD46 (membrane cofactor protein) after alternative but not classical complement activation, European Journal of Immunology, vol.156, issue.3, pp.815-822, 1999.
DOI : 10.1002/(SICI)1521-4141(199903)29:03<815::AID-IMMU815>3.0.CO;2-8

B. Dubois, B. Vanbervliet, J. Fayette, C. Massacrier, C. Van-kooten et al., Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes, The Journal of Experimental Medicine, vol.154, issue.5, pp.941-951, 1997.
DOI : 10.1084/jem.182.2.389

D. Naniche, G. Varior-krishnan, F. Cervoni, T. F. Wild, B. Rossi et al., Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus, J. Virol, vol.67, pp.6025-6032, 1993.

E. S. Reis, J. A. Barbuto, J. Köhl, and L. Isaac, Impaired dendritic cell differentiation and maturation in the absence of C3, Molecular Immunology, vol.45, issue.7, pp.1952-1962, 2008.
DOI : 10.1016/j.molimm.2007.10.031

K. Agematsu, H. Nagumo, F. C. Yang, T. Nakazawa, K. Fukushima et al., B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production, European Journal of Immunology, vol.268, issue.8, pp.2073-2079, 1997.
DOI : 10.1002/eji.1830270835

S. Weller, C. Reynaud, and J. Weill, Splenic marginal zone B cells in humans: Where do they mutate their Ig receptor?, European Journal of Immunology, vol.22, issue.10, pp.2789-2792, 2005.
DOI : 10.1002/eji.200535446

URL : https://hal.archives-ouvertes.fr/inserm-00336844

C. Kemper, A. C. Chan, J. M. Green, K. A. Brett, K. M. Murphy et al., Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype, Nature, vol.274, issue.6921, pp.388-392, 2003.
DOI : 10.1038/nature01315

W. Barchet, J. D. Price, M. Cella, M. Colonna, S. K. Macmillan et al., Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation, Blood, vol.107, issue.4, pp.1497-1504, 2006.
DOI : 10.1182/blood-2005-07-2951

U. R. Nilsson, B. Nilsson, K. E. Storm, G. Sjölin-forsberg, and R. Hällgren, Hereditary dysfunction of the third component of complement associated with a systemic lupus erythematosus-like syndrome and meningococcal meningitis, Arthritis & Rheumatism, vol.32, issue.5, pp.580-586, 1992.
DOI : 10.1002/art.1780350516

B. J. Janssen, E. G. Huizinga, H. C. Raaijmakers, A. Roos, M. R. Daha et al., Structures of complement component C3 provide insights into the function and evolution of immunity, Nature, vol.256, issue.7058, pp.505-511, 2005.
DOI : 10.1016/j.gene.2003.11.025

G. G. Klaus and J. H. Humphrey, The generation of memory cells. I. The role of C3 in the generation of B memory cells, Immunology, vol.33, pp.31-40, 1977.

M. C. Carroll, The complement system in B cell regulation, Molecular Immunology, vol.41, issue.2-3, pp.141-146, 2004.
DOI : 10.1016/j.molimm.2004.03.017

U. Klein, K. Rajewsky, and R. Kuppers, Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells, The Journal of Experimental Medicine, vol.154, issue.9, pp.1679-1689, 1998.
DOI : 10.1038/ng0193-88

U. Karrer, C. López-macías, A. Oxenius, B. Odermatt, M. F. Bachmann et al., Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1-/- Mice, The Journal of Immunology, vol.164, issue.2, pp.768-778, 2000.
DOI : 10.4049/jimmunol.164.2.768

J. C. Marie, A. L. Astier, P. Rivailler, C. Rabourdin-combe, T. F. Wild et al., Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell???induced inflammation, Nature Immunology, vol.3, pp.659-666, 2002.
DOI : 10.1038/ni810

C. Kemper and J. P. Atkinson, T-cell regulation: with complements from innate immunity, Nature Reviews Immunology, vol.50, issue.1, pp.9-18, 2007.
DOI : 10.1038/nri1994

A. Fuchs, V. Frémeaux-bacchi, and C. Kemper, A role for complement (CD46)-activated T cells in generating optimal B cell responses, Molecular Immunology, vol.44, issue.16, pp.3909-3910, 2007.
DOI : 10.1016/j.molimm.2007.06.009

C. R. Ruprecht and A. Lanzavecchia, Toll-like receptor stimulation as a third signal required for activation of human naive B cells, European Journal of Immunology, vol.20, issue.4, pp.810-816, 2006.
DOI : 10.1002/eji.200535744

A. Bernet and P. Mehlen, Dependence receptors: when apoptosis controls tumor progression, Bull. Cancer, vol.94, pp.12-17, 2007.

A. Verschoor, M. A. Brockman, M. Gadjeva, D. M. Knipe, and M. C. Carroll, Myeloid C3 Determines Induction of Humoral Responses to Peripheral Herpes Simplex Virus Infection, The Journal of Immunology, vol.171, issue.10, pp.5363-5371, 2003.
DOI : 10.4049/jimmunol.171.10.5363