Skip to Main content Skip to Navigation
Journal articles

Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.

Abstract : Chronic intoxication by 3-nitropropionic acid in the Lewis rat reproduces many features reminiscent of Huntington's disease including behavioural alterations and cortico-striatal degeneration. In particular, in this model, striatal degeneration is accompanied by calpain activation as found in the human disease. The present study was undertaken to determine whether the expression of Alix (apoptosis linked gene-2 interacting protein), a widespread protein involved in neuronal death, would be modified in the striatum and cortex of 3NP-treated rats. The results clearly show that Alix immunoreactivity is increased in the neuronal cell bodies of the lateral striatum, where degeneration is massive. The medial striatum and the cortex that lack neurodegeneration remain only weakly labelled. This is further evidence suggesting an involvement of Alix in the events driving neuronal death.
Document type :
Journal articles
Complete list of metadatas

Cited literature [29 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00381837
Contributor : Sandrine Fraboulet <>
Submitted on : Tuesday, July 19, 2011 - 11:30:04 AM
Last modification on : Friday, November 6, 2020 - 3:48:21 AM
Long-term archiving on: : Friday, December 2, 2016 - 4:53:31 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

UGA

Citation

David Blum, Fiona Hemming, Marie-Christine Galas, Sakina Torch, Laetitia Cuvelier, et al.. Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.. Neuroscience Letters, Elsevier, 2004, 368 (3), pp.309-13. ⟨10.1016/j.neulet.2004.07.046⟩. ⟨inserm-00381837⟩

Share

Metrics

Record views

416