Skip to Main content Skip to Navigation
Journal articles

Alix differs from ESCRT proteins in the control of autophagy.

Abstract : Alix/AIP1 is a cytosolic protein that regulates cell death through mechanisms that remain unclear. Alix binds to two protein members of the so-called Endosomal Sorting Complex Required for Transport (ESCRT), which facilitates membrane fission events during multivesicular endosome formation, enveloped virus budding and cytokinesis. Alix itself has been suggested to participate in these cellular events and is thus often considered to function in the ESCRT pathway. ESCRT proteins were recently implicated in autophagy, a process involved in bulk degradation of cytoplasmic constituents in lysosomes, which can also participate in cell death. In this study, we shown that, unlike ESCRT proteins, Alix is not involved in autophagy. These results strongly suggest that the capacity of several mutants of Alix to block both caspase-dependent and independent cell death does not relate to their capacity to modulate autophagy. Furthermore, they reinforce the conclusion of other studies demonstrating that the role of Alix is different from that of classical ESCRT proteins.
Document type :
Journal articles
Complete list of metadata

Cited literature [33 references]  Display  Hide  Download
Contributor : Sandrine Fraboulet Connect in order to contact the contributor
Submitted on : Tuesday, July 12, 2011 - 5:26:43 PM
Last modification on : Friday, November 6, 2020 - 4:07:18 AM
Long-term archiving on: : Saturday, December 3, 2016 - 12:08:43 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Anne Petiot, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, Sakina Torch, et al.. Alix differs from ESCRT proteins in the control of autophagy.. Biochemical and Biophysical Research Communications, Elsevier, 2008, 375 (1), pp.63-8. ⟨10.1016/j.bbrc.2008.07.136⟩. ⟨inserm-00381803⟩



Record views