Alix and ALG-2 make a link between endosomes and neuronal death. - Archive ouverte HAL Access content directly
Journal Articles Biochemical Society Transactions Year : 2009

Alix and ALG-2 make a link between endosomes and neuronal death.

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Abstract

Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved in endosomal trafficking, the genuine function of the protein in this process remains unclear. We have demonstrated recently that Alix and ALG-2 form in the presence of calcium, a complex with apical caspases and with the endocytosed death receptor TNFR1 (tumour necrosis factor alpha receptor 1), thus suggesting a molecular coupling between endosomes and the cell death machinery.
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inserm-00381793 , version 1 (12-07-2011)

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Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, et al.. Alix and ALG-2 make a link between endosomes and neuronal death.. Biochemical Society Transactions, 2009, 37 (Pt 1), pp.200-3. ⟨10.1042/BST0370200⟩. ⟨inserm-00381793⟩

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