Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels. - Archive ouverte HAL Access content directly
Journal Articles Journal of Peptide Science Year : 2005

Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels.

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Abstract

The 'functional dyad', a well-defined pair of amino acid residues (basic and hydrophobic residues), is a key molecular determinant present in most animal toxins acting on voltage-gated Kv1 channels. It is increasingly used as a working concept to explain how toxins are able to recognize and block their specific ion channel targets. However, other crucial toxin determinants are emerging and the actual role of this 'functional dyad' ought to be clarified, which is the object of the present mini-review.

Dates and versions

inserm-00381750 , version 1 (06-05-2009)

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Stephanie Mouhat, Michel de Waard, Jean-Marc Sabatier. Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels.. Journal of Peptide Science, 2005, 11 (2), pp.65-8. ⟨10.1002/psc.630⟩. ⟨inserm-00381750⟩
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