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Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.

Nils Kickler 1, * Paul Krack 2, 3 Valérie Fraix 2, 3 Jean-François Lebas 4 Laurent Lamalle 1 Franck Durif 5 Alexandre Krainik 1 Chantal Rémy 1 Christoph Segebarth 1 Pierre Pollak 2, 3 
* Corresponding author
5 Pharmacologie fondamentale et clinique de la douleur
Neuro-Dol - Neuro-Dol, UdA - Université d'Auvergne - Clermont-Ferrand I, INSERM - Institut National de la Santé et de la Recherche Médicale : U766
Abstract : Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity (TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed.
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Nils Kickler, Paul Krack, Valérie Fraix, Jean-François Lebas, Laurent Lamalle, et al.. Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.. NMR in Biomedicine, Wiley, 2007, 20 (8), pp.757-62. ⟨10.1002/nbm.1141⟩. ⟨inserm-00381742⟩



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