Skip to Main content Skip to Navigation
Journal articles

Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.

Abstract : Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity (TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed.
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00381742
Contributor : Michel Dojat <>
Submitted on : Monday, August 17, 2009 - 4:48:50 PM
Last modification on : Friday, November 6, 2020 - 3:45:20 AM
Long-term archiving on: : Saturday, November 26, 2016 - 9:18:41 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Nils Kickler, Paul Krack, Valérie Fraix, Jean-François Lebas, Laurent Lamalle, et al.. Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.. NMR in Biomedicine, Wiley, 2007, 20 (8), pp.757-62. ⟨10.1002/nbm.1141⟩. ⟨inserm-00381742⟩

Share

Metrics

Record views

278