Skip to Main content Skip to Navigation
Journal articles

Controlling seizures is not controlling epilepsy: a parametric study of deep brain stimulation for epilepsy.

Abstract : Pharmacological inhibition and high-frequency stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate stimulation procedures are still needed.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00381732
Contributor : Colin Deransart <>
Submitted on : Wednesday, May 6, 2009 - 2:32:56 PM
Last modification on : Friday, March 6, 2020 - 1:44:57 AM

Identifiers

Collections

UGA

Citation

Berend Feddersen, Laurent Vercueil, Soheyl Noachtar, Olivier David, Antoine Depaulis, et al.. Controlling seizures is not controlling epilepsy: a parametric study of deep brain stimulation for epilepsy.. Neurobiology of Disease, Elsevier, 2007, 27 (3), pp.292-300. ⟨10.1016/j.nbd.2007.05.005⟩. ⟨inserm-00381732⟩

Share

Metrics

Record views

157