Skip to Main content Skip to Navigation
Journal articles

[Voltage-dependent calcium channels at the heart of pain perception]

Abstract : Voltage-dependent calcium channels represent a major pathway of calcium entry into neurons, where they participate actively to cell excitability and to the molecular processes of synaptic transmission. For that reason, they have been the direct or indirect pharmacological targets of analgesics and this long before their implication in the physiology of nociception had been demonstrated. These last years, the still more refined molecular characterization of these channels and their associated regulatory subunits and the demonstration of their implication in nociceptive processes indicates that these structures are prime pharmacological targets for the management of pain. Herein, we detail the recent breakthroughs on calcium channel structure, function and pharmacology, review the implication of calcium channels in the transmission of nociception, and evaluate their importance as targets for the treatment of pain perception. The search for specific inhibitors of voltage-dependent calcium channels appears as a prelude to the development of new promising analgesic molecules.
Complete list of metadatas

Cited literature [49 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00381717
Contributor : Marco Canepari <>
Submitted on : Wednesday, May 6, 2009 - 4:39:19 PM
Last modification on : Wednesday, May 6, 2009 - 4:39:58 PM
Long-term archiving on: : Thursday, June 10, 2010 - 10:51:08 PM

File

DeWaard.pdf.pdf
Publisher files allowed on an open archive

Identifiers

  • HAL Id : inserm-00381717, version 1
  • PUBMED : 16597409

Collections

CEA | U836 | UGA

Citation

Norbert Weiss, Michel de Waard. [Voltage-dependent calcium channels at the heart of pain perception]. médecine/sciences, EDP Sciences, 2006, 22 (4), pp.396-404. ⟨inserm-00381717⟩

Share

Metrics

Record views

684

Files downloads

1569