R. Roberts and . Genomics, Genomics and Cardiac Arrhythmias, Journal of the American College of Cardiology, vol.47, issue.1, pp.9-21, 2006.
DOI : 10.1016/j.jacc.2005.08.059

P. Schwartz, The congenital long QT syndromes from genotype to phenotype: clinical implications, Journal of Internal Medicine, vol.26, issue.1, pp.39-47, 2006.
DOI : 10.1161/01.CIR.0000125524.34234.13

J. Lupoglazoff, I. Denjoy, and E. Villain, Long QT syndrome in neonates, Journal of the American College of Cardiology, vol.43, issue.5, pp.826-856, 2004.
DOI : 10.1016/j.jacc.2003.09.049

C. Chang, S. Acharfi, and M. Wu, A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia, Cardiovascular Research, vol.64, issue.2, pp.268-78, 2004.
DOI : 10.1016/j.cardiores.2004.07.007

S. Lehnart, M. Ackerman, B. Jr, and D. , Inherited Arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function, Circulation, vol.116, issue.20, pp.2325-2370, 2007.
DOI : 10.1161/CIRCULATIONAHA.107.711689

Q. Wang, J. Shen, and I. Splawski, SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome, Cell, vol.80, issue.5, pp.1-20, 1995.
DOI : 10.1016/0092-8674(95)90359-3

M. Curran, I. Splawski, and K. Timothy, A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome, Cell, vol.80, issue.5, pp.795-803, 1995.
DOI : 10.1016/0092-8674(95)90358-5

E. Schulze-bahr, H. Fenge, and D. Etzrodt, Long QT syndrome and life threatening arrhythmia in a newborn: molecular diagnosis and treatment response, Heart, vol.90, issue.1, pp.13-16, 2004.
DOI : 10.1136/heart.90.1.13

Z. Wang, H. Li, and A. Moss, Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome, Molecular Genetics and Metabolism, vol.75, issue.4, pp.308-316, 2002.
DOI : 10.1016/S1096-7192(02)00007-0

L. Lasen, I. Fosdal, and P. Anderson, Recessive Romano-Ward syndrome associated with compound heterozygosity for two mutations in the KVLQT1 gene

M. Yamaguchi, M. Shimizu, and H. Ino, associated with severe long QT syndrome, Clinical Science, vol.108, issue.2, pp.143-50, 2005.
DOI : 10.1042/CS20040220

W. Shimizu, T. Aiba, and C. Antzelevitch, Specific Therapy Based on the Genotype and Cellular Mechanism in Inherited Cardiac Arrhythmias. Long QT Syndrome and Brugada Syndrome, Current Pharmaceutical Design, vol.11, issue.12, pp.1561-72, 2005.
DOI : 10.2174/1381612053764823

Y. Ruan, N. Liu, and R. Bloise, Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients, Circulation, vol.116, issue.10, pp.1137-1181, 2007.
DOI : 10.1161/CIRCULATIONAHA.107.707877

M. Chahine, L. Chen, and R. Barchi, Lidocaine block of human heart sodium channels expressed in Xenopus oocytes, Journal of Molecular and Cellular Cardiology, vol.24, issue.11, pp.1231-1237, 1992.
DOI : 10.1016/0022-2828(92)93090-7

R. Margolskee, B. Mchendry-rinde, and R. Horn, Panning transfected cells for electrophysiological studies, Biotechniques, vol.15, pp.906-917, 1993.

D. Keller, S. Acharfi, and E. Delacretaz, A novel mutation in SCN5A, delQKP 1507???1509, causing long QT syndrome: Role of Q1507 residue in sodium channel inactivation, Journal of Molecular and Cellular Cardiology, vol.35, issue.12, pp.1513-1534, 2003.
DOI : 10.1016/j.yjmcc.2003.08.007

O. Hamill, M. A. Neher, and E. , Improved patch-clamp techniques for 19 high-resolution current recording from cells and cell-free membrane patches, pp.85-100, 1981.

E. Roti, C. Myers, and R. Ayers, Interaction with GM130 during HERG Ion Channel Trafficking: DISRUPTION BY TYPE 2 CONGENITAL LONG QT SYNDROME MUTATIONS, Journal of Biological Chemistry, vol.277, issue.49, pp.47779-85, 2002.
DOI : 10.1074/jbc.M206638200

I. Chang, M. Shyu, and C. Lee, Prenatal diagnosis and treatment of fetal long QT syndrome: a case report, Prenatal Diagnosis, vol.110, issue.13, pp.1209-1221, 2002.
DOI : 10.1002/pd.475

H. Tan, Sodium Channel Variants in Heart Disease: Expanding Horizons, Journal of Cardiovascular Electrophysiology, vol.83, issue.s1, pp.151-157, 2006.
DOI : 10.1007/s000180050306

B. Blasco, P. , A. Jimenez, M. , F. Gonzalez et al., Neonatal life-threatening arrhythmia responding to lidocaine, a probable LQTS3, International Journal of Cardiology, vol.117, issue.2, pp.61-64, 2007.
DOI : 10.1016/j.ijcard.2006.11.126

M. Wu, M. Su, and H. Lue, Age-related Quinidine Effects on Ionic Currents of Rabbit Cardiac Myocytes, Journal of Molecular and Cellular Cardiology, vol.26, issue.9, pp.1167-77, 1994.
DOI : 10.1006/jmcc.1994.1135

E. Levy-nissenbaum, M. Eldar, and Q. Wang, Genetic Analysis of Brugada Syndrome in Israel: Two Novel Mutations and Possible Genetic Heterogeneity, Genetic Testing, vol.5, issue.4, pp.331-335, 2001.
DOI : 10.1089/109065701753617480

G. Millat, P. Chevalier, and L. Restier-miron, Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome, Clinical Genetics, vol.348, issue.Suppl, pp.214-241, 2006.
DOI : 10.1111/j.1399-0004.2006.00671.x

S. Priori, C. Napolitano, and M. Gasparini, Natural History of Brugada Syndrome: Insights for Risk Stratification and Management, Circulation, vol.105, issue.11, pp.1342-1389, 2002.
DOI : 10.1161/hc1102.105288

M. Vatta, R. Dumaine, and C. Antzelevitch, Novel mutations in domain I of 20

I. Splawski, J. Shen, and K. Timothy, Spectrum of Mutations in Long-QT Syndrome Genes : KVLQT1, HERG, SCN5A, KCNE1, and KCNE2, Circulation, vol.102, issue.10, pp.1178-85, 2000.
DOI : 10.1161/01.CIR.102.10.1178

A. Moss, W. Zareba, and E. Kaufman, Increased Risk of Arrhythmic Events in Long-QT Syndrome With Mutations in the Pore Region of the Human Ether-a-go-go-Related Gene Potassium Channel, Circulation, vol.105, issue.7, pp.794-803, 2002.
DOI : 10.1161/hc0702.105124

M. Sanguinetti, M. Curran, and P. Spector, Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia., Proceedings of the National Academy of Sciences, vol.93, issue.5, pp.2208-2220, 1996.
DOI : 10.1073/pnas.93.5.2208