The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate, Journal of Medicinal Chemistry, vol.36, issue.12, pp.1716-1725, 1993. ,
DOI : 10.1021/jm00064a005
Giant synaptic potentials in immature rat CA3 hippocampal neurones., The Journal of Physiology, vol.416, issue.1, pp.303-325, 1989. ,
DOI : 10.1113/jphysiol.1989.sp017762
Long-lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic acid., The Journal of Physiology, vol.404, issue.1, pp.365-384, 1988. ,
DOI : 10.1113/jphysiol.1988.sp017294
GABAA, NMDA and AMPA receptors: a developmentally regulated 'm??nage ?? trois', Trends in Neurosciences, vol.20, issue.11, pp.523-529, 1997. ,
DOI : 10.1016/S0166-2236(97)01147-8
Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus, Journal of Neuroscience, vol.23, pp.6826-6836, 2003. ,
GABAB receptors: drugs meet clones, Current Opinion in Neurobiology, vol.8, issue.3, pp.345-350, 1998. ,
DOI : 10.1016/S0959-4388(98)80059-7
Molecular Structure and Physiological Functions of GABAB Receptors, Physiological Reviews, vol.84, issue.3, pp.835-867, 2004. ,
DOI : 10.1152/physrev.00036.2003
Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model, Science, vol.271, issue.5247, pp.369-373, 1996. ,
DOI : 10.1126/science.271.5247.369
G-protein-coupled receptors: turn-ons and turn-offs, Current Opinion in Neurobiology, vol.8, issue.3, 1998. ,
DOI : 10.1016/S0959-4388(98)80058-5
Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits, Nat.Med, vol.5, pp.888-894, 1999. ,
GABA: an excitatory transmitter in early postnatal life, Trends in Neurosciences, vol.14, issue.12, pp.515-519, 1991. ,
DOI : 10.1016/0166-2236(91)90003-D
Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling, Nat.Neurosci, vol.5, pp.415-424, 2002. ,
Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus., The Journal of Physiology, vol.424, issue.1, pp.1224-1233, 1990. ,
DOI : 10.1113/jphysiol.1990.sp018080
Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient, Journal of Neuroscience, vol.17, pp.7662-7672, 1997. ,
A novel in vitro preparation: the intact hippocampal formation, Neuron, vol.19, pp.743-749, 1997. ,
URL : https://hal.archives-ouvertes.fr/inserm-00522462
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures, Nature Neuroscience, vol.6, issue.10, pp.1079-1085, 2003. ,
DOI : 10.1038/nn1125
URL : https://hal.archives-ouvertes.fr/inserm-00484787
Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices., The Journal of Physiology, vol.498, issue.3, pp.763-772, 1997. ,
DOI : 10.1113/jphysiol.1997.sp021900
Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations, Journal of Neuroscience, vol.20, pp.6820-6829, 2000. ,
Changes in GABAB receptor immunoreactivity after recurrent seizures in rats, Neuroscience Letters, vol.315, issue.1-2, pp.85-88, 2001. ,
DOI : 10.1016/S0304-3940(01)02350-3
Profound disturbances of pre-and postsynaptic GABABreceptor-mediated processes in region CA1 in a chronic model of temporal lobe epilepsy, Journal of Neurophysiology, vol.76, pp.1282-1296, 1996. ,
Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus, Journal of Neurophysiology, vol.76, pp.1036-1046, 1996. ,
Kindling and status epilepticus models of epilepsy: rewiring the brain, Progress in Neurobiology, vol.73, issue.1, pp.1-60, 2004. ,
DOI : 10.1016/j.pneurobio.2004.03.009
GABAB receptor activation promotes seizure activity in the juvenil rat hippocampus, Journal of Neurophysiology, vol.82, issue.647, 1999. ,
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice, Mol.Cell Neurosci, vol.17, pp.1059-1070, 2001. ,
Factors Contributing to the Decay of the Stimulus-Evoked IPSC in Rat Hippocampal CA1 Neurons, Journal of Neurophysiology, vol.72, pp.2911-2926, 1994. ,
Epileptiform activity induced by changes in extracellular potassium in hippocampus, Journal of Neurophysiology, vol.54, pp.1363-1374, 1985. ,
impaired memory, and loss of pre-and postsynaptic GABA(B) responses in mice lacking GABA(B(1)), Neuron, vol.31, pp.47-58 ,
Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors, Science, vol.269, issue.5226, pp.977-981, 1995. ,
DOI : 10.1126/science.7638623
Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy, European Journal of Neuroscience, vol.3, issue.8, pp.2213-2226, 2003. ,
DOI : 10.1016/S0306-4522(02)00264-6
Acute desensitization of presynaptic GABAB-mediated inhibition and induction of epileptiform discharges in the neonatal rat hippocampus, European Journal of Neuroscience, vol.57, issue.12, pp.3227-3234, 2004. ,
DOI : 10.1111/j.0953-816X.2004.03413.x
URL : https://hal.archives-ouvertes.fr/inserm-00484569
Downregulation of G protein-coupled receptors, Current Opinion in Neurobiology, vol.10, issue.3, pp.365-369, 2000. ,
DOI : 10.1016/S0959-4388(00)00096-9
Synchronization of GABAergic interneuronal networks during seizure-like activity in the rat horizontal hippocampal slice, European Journal of Neuroscience, vol.18, issue.5, pp.4110-4118, 1999. ,
DOI : 10.1046/j.1460-9568.1999.00837.x
Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells, Annals of Neurology, vol.78, issue.6, pp.729-738, 2000. ,
DOI : 10.1002/1531-8249(200006)47:6<729::AID-ANA5>3.0.CO;2-C
URL : https://hal.archives-ouvertes.fr/inserm-00485225
Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors, Journal of Neuroscience, vol.22, pp.1248-1255, 2002. ,
Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1, Journal of Neuroscience, vol.17, pp.9261-9269, 1997. ,