K. E. Andersen, C. Braestrup, F. C. Gronwald, A. S. Jorgensen, E. B. Nielsen et al., The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate, Journal of Medicinal Chemistry, vol.36, issue.12, pp.1716-1725, 1993.
DOI : 10.1021/jm00064a005

Y. Ben-ari, E. Cherubini, R. Corradetti, and J. Gaïarsa, Giant synaptic potentials in immature rat CA3 hippocampal neurones., The Journal of Physiology, vol.416, issue.1, pp.303-325, 1989.
DOI : 10.1113/jphysiol.1989.sp017762

Y. Ben-ari and M. Gho, Long-lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic acid., The Journal of Physiology, vol.404, issue.1, pp.365-384, 1988.
DOI : 10.1113/jphysiol.1988.sp017294

Y. Ben-ari, R. Khazipov, X. Leinekugel, O. Caillard, and J. Gaïarsa, GABAA, NMDA and AMPA receptors: a developmentally regulated 'm??nage ?? trois', Trends in Neurosciences, vol.20, issue.11, pp.523-529, 1997.
DOI : 10.1016/S0166-2236(97)01147-8

R. A. Bender, S. V. Soleymani, A. L. Brewster, S. T. Nguyen, H. Beck et al., Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus, Journal of Neuroscience, vol.23, pp.6826-6836, 2003.

B. Bettler, K. Kaupmann, and N. Bowery, GABAB receptors: drugs meet clones, Current Opinion in Neurobiology, vol.8, issue.3, pp.345-350, 1998.
DOI : 10.1016/S0959-4388(98)80059-7

B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann, Molecular Structure and Physiological Functions of GABAB Receptors, Physiological Reviews, vol.84, issue.3, pp.835-867, 2004.
DOI : 10.1152/physrev.00036.2003

E. H. Buhl, T. S. Otis, and I. Mody, Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model, Science, vol.271, issue.5247, pp.369-373, 1996.
DOI : 10.1126/science.271.5247.369

C. V. Carman and J. L. Benovic, G-protein-coupled receptors: turn-ons and turn-offs, Current Opinion in Neurobiology, vol.8, issue.3, 1998.
DOI : 10.1016/S0959-4388(98)80058-5

K. Chen, T. Z. Baram, and I. Soltesz, Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits, Nat.Med, vol.5, pp.888-894, 1999.

E. Cherubini, J. Gaïarsa, and Y. Ben-ari, GABA: an excitatory transmitter in early postnatal life, Trends in Neurosciences, vol.14, issue.12, pp.515-519, 1991.
DOI : 10.1016/0166-2236(91)90003-D

A. Couve, P. Thomas, A. R. Calver, W. D. Hirst, M. N. Pangalos et al., Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling, Nat.Neurosci, vol.5, pp.415-424, 2002.

C. H. Davies, S. N. Davies, and G. L. Collingridge, Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus., The Journal of Physiology, vol.424, issue.1, pp.1224-1233, 1990.
DOI : 10.1113/jphysiol.1990.sp018080

K. Kaila, K. Lamsa, S. Smirnov, T. Taira, and J. Voipio, Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient, Journal of Neuroscience, vol.17, pp.7662-7672, 1997.

Y. Ari, A novel in vitro preparation: the intact hippocampal formation, Neuron, vol.19, pp.743-749, 1997.
URL : https://hal.archives-ouvertes.fr/inserm-00522462

I. Khalilov, G. L. Holmes, and Y. Ari, In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures, Nature Neuroscience, vol.6, issue.10, pp.1079-1085, 2003.
DOI : 10.1038/nn1125

URL : https://hal.archives-ouvertes.fr/inserm-00484787

R. Khazipov, X. Leinekugel, I. Khalilov, J. Gaïarsa, and Y. Ben-ari, Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices., The Journal of Physiology, vol.498, issue.3, pp.763-772, 1997.
DOI : 10.1113/jphysiol.1997.sp021900

R. Kohling, M. Vreugdenhil, E. Bracci, and J. G. Jefferys, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations, Journal of Neuroscience, vol.20, pp.6820-6829, 2000.

Z. Kokaia and M. Kokaia, Changes in GABAB receptor immunoreactivity after recurrent seizures in rats, Neuroscience Letters, vol.315, issue.1-2, pp.85-88, 2001.
DOI : 10.1016/S0304-3940(01)02350-3

P. S. Mangan and E. W. Lothman, Profound disturbances of pre-and postsynaptic GABABreceptor-mediated processes in region CA1 in a chronic model of temporal lobe epilepsy, Journal of Neurophysiology, vol.76, pp.1282-1296, 1996.

H. A. Mclean, O. Caillard, R. Khazipov, Y. Ben-ari, and J. Gaïarsa, Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus, Journal of Neurophysiology, vol.76, pp.1036-1046, 1996.

K. Morimoto, M. Fahnestock, and R. J. Racine, Kindling and status epilepticus models of epilepsy: rewiring the brain, Progress in Neurobiology, vol.73, issue.1, pp.1-60, 2004.
DOI : 10.1016/j.pneurobio.2004.03.009

R. Motalli, J. Louvel, V. Tancredi, I. Kurcewicz, D. Wan-chow-wah et al., GABAB receptor activation promotes seizure activity in the juvenil rat hippocampus, Journal of Neurophysiology, vol.82, issue.647, 1999.

E. Lanneau, C. Gray, J. Schenck, E. Warmerdam, B. S. Clapham et al., Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice, Mol.Cell Neurosci, vol.17, pp.1059-1070, 2001.

A. Roepstorff and J. D. Lambert, Factors Contributing to the Decay of the Stimulus-Evoked IPSC in Rat Hippocampal CA1 Neurons, Journal of Neurophysiology, vol.72, pp.2911-2926, 1994.

P. A. Rutecki, F. J. Lebeda, and D. Johnston, Epileptiform activity induced by changes in extracellular potassium in hippocampus, Journal of Neurophysiology, vol.54, pp.1363-1374, 1985.

H. Epilepsy, impaired memory, and loss of pre-and postsynaptic GABA(B) responses in mice lacking GABA(B(1)), Neuron, vol.31, pp.47-58

K. J. Staley, B. L. Soldo, and W. R. Proctor, Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors, Science, vol.269, issue.5226, pp.977-981, 1995.
DOI : 10.1126/science.7638623

A. Straessle, F. Loup, D. Arabadzisz, G. V. Ohning, and J. M. Fritschy, Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy, European Journal of Neuroscience, vol.3, issue.8, pp.2213-2226, 2003.
DOI : 10.1016/S0306-4522(02)00264-6

P. Tosetti, R. Bakels, I. Colin-le-brun, N. Ferrand, J. L. Gaïarsa et al., Acute desensitization of presynaptic GABAB-mediated inhibition and induction of epileptiform discharges in the neonatal rat hippocampus, European Journal of Neuroscience, vol.57, issue.12, pp.3227-3234, 2004.
DOI : 10.1111/j.0953-816X.2004.03413.x

URL : https://hal.archives-ouvertes.fr/inserm-00484569

P. Tsao and M. Von-zastrow, Downregulation of G protein-coupled receptors, Current Opinion in Neurobiology, vol.10, issue.3, pp.365-369, 2000.
DOI : 10.1016/S0959-4388(00)00096-9

J. L. Velazquez and P. L. Carlen, Synchronization of GABAergic interneuronal networks during seizure-like activity in the rat horizontal hippocampal slice, European Journal of Neuroscience, vol.18, issue.5, pp.4110-4118, 1999.
DOI : 10.1046/j.1460-9568.1999.00837.x

N. Villeneuve, Y. Ben-ari, G. L. Holmes, and J. Gaïarsa, Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells, Annals of Neurology, vol.78, issue.6, pp.729-738, 2000.
DOI : 10.1002/1531-8249(200006)47:6<729::AID-ANA5>3.0.CO;2-C

URL : https://hal.archives-ouvertes.fr/inserm-00485225

J. P. Wetherington and N. A. Lambert, Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors, Journal of Neuroscience, vol.22, pp.1248-1255, 2002.

C. Wu and L. S. Leung, Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1, Journal of Neuroscience, vol.17, pp.9261-9269, 1997.