MCAK associates with the tips of polymerizing microtubules. - Archive ouverte HAL Access content directly
Journal Articles Journal of Cell Biology Year : 2005

MCAK associates with the tips of polymerizing microtubules.

(1) , (1) , (2) , (3) , (1) , (1) , (3) , (3) , (1)
1
2
3

Abstract

MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells. Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-terminal tail of MCAK. Tip tracking is not essential for MCAK's MT-depolymerizing activity. We propose that tip tracking is a mechanism by which MCAK is preferentially localized to regions of the cell that modulate the plus ends of MTs.
Fichier principal
Vignette du fichier
Moores2005.pdf (1.9 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-00380214 , version 1 (13-05-2009)

Identifiers

Cite

Ayana T. Moore, Kathleen E. Rankin, George von Dassow, Leticia Peris, Michael Wagenbach, et al.. MCAK associates with the tips of polymerizing microtubules.. Journal of Cell Biology, 2005, 169 (3), pp.391-7. ⟨10.1083/jcb.200411089⟩. ⟨inserm-00380214⟩
128 View
273 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More