STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating.

Rosa Fradley 1, * Gillian O'Meara 1 Richard Newman 1 Annie Andrieux 2 Didier Job 2 David Reynolds 1
* Auteur correspondant
1 Neuroscience Research Centre
2 Organisation Fonctionnelle du Cytosquelette
Abstract : Schizophrenia is a chronic and debilitating disease which is thought to arise from a neuro-developmental disorder. Both the stable tubule-only polypeptide (STOP) protein and the N-methyl-D-aspartate (NMDA) NR1 subunit are involved in neuronal development and physiology. It has therefore been postulated that transgenic mice lacking either the STOP or the NMDAR1 gene would show a 'schizophrenic-like' phenotype. Here, STOP knockout and NMDA NR1 hypomorphic mice were assessed in a behavioural measure that can be used to detect schizophrenic-like phenotypes: a change in sensorimotor gating, measured through prepulse inhibition (PPI). STOP knockout mice were further assessed in another measure of 'schizophrenic-like behaviour': hyperlocomotion. The PPI deficit exhibited by both the STOP knockout and NMDA knockdown mice could not be reversed by acute treatment with the atyptical antipsychotic, clozapine (1 mg/kg, i.p.) but the hyperlocomotion shown by the STOP knockout mice was reversed with the same acute dose of clozapine.
Keywords : Schizophrenia Neuro-developmental disorder PPI Sensorimotor-gating Hyperlocomotion NMDA NR1 hypomorphic mice STOP KO mice
Type de document :
Article dans une revue
Behavioural Brain Research, Elsevier, 2005, 163 (2), pp.257-64. 〈10.1016/j.bbr.2005.05.012〉
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Contributeur : Annie Andrieux <>
Soumis le : jeudi 16 juillet 2009 - 17:13:48
Dernière modification le : vendredi 19 octobre 2018 - 11:48:03
Document(s) archivé(s) le : samedi 26 novembre 2016 - 08:35:44

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Rosa Fradley, Gillian O'Meara, Richard Newman, Annie Andrieux, Didier Job, et al.. STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating.. Behavioural Brain Research, Elsevier, 2005, 163 (2), pp.257-64. 〈10.1016/j.bbr.2005.05.012〉. 〈inserm-00380197〉

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