A. Andrieux, P. A. Salin, M. Vernet, P. Kujala, J. Baratier et al., The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders, Genes & Development, vol.16, issue.18, pp.2350-2364, 2002.
DOI : 10.1101/gad.223302

L. Guillaud, C. Bosc, A. Fourest-lieuvin, E. Denarier, F. Pirollet et al., STOP Proteins are Responsible for the High Degree of Microtubule Stabilization Observed in Neuronal Cells, The Journal of Cell Biology, vol.15, issue.1, pp.167-179, 1998.
DOI : 10.1083/jcb.133.1.151

C. Bosc, R. Frank, E. Denarier, M. Ronjat, A. Schweitzer et al., Identification of Novel Bifunctional Calmodulin-binding and Microtubule-stabilizing Motifs in STOP Proteins, Journal of Biological Chemistry, vol.276, issue.33, pp.30904-30913, 2001.
DOI : 10.1074/jbc.M011614200

P. Brun, M. Bégou, A. Andrieux, L. Mouly-badina, M. Clerget et al., Dopaminergic transmission in STOP null mice, Journal of Neurochemistry, vol.65, issue.1, pp.63-73, 2005.
DOI : 10.1016/0165-0173(90)90015-G

URL : https://hal.archives-ouvertes.fr/inserm-00380189

E. Denarier, M. Aguezzoul, C. Jolly, C. Vourc-'h, A. Roure et al., Genomic Structure and Chromosomal Mapping of the Mouse STOP Gene (Mtap6), Biochemical and Biophysical Research Communications, vol.243, issue.3, pp.791-796, 1998.
DOI : 10.1006/bbrc.1998.8179

M. R. Galiano, C. Bosc, A. Schweitzer, A. Andrieux, D. Job et al., Astrocytes and oligodendrocytes express different STOP protein isoforms, Journal of Neuroscience Research, vol.19, issue.3, pp.329-337, 2004.
DOI : 10.1002/jnr.20260

A. C. Horton and M. D. Ehlers, Secretory trafficking in neuronal dendrites, Nature Cell Biology, vol.14, issue.7, pp.585-591, 2004.
DOI : 10.1038/nrn785

J. D. Thompson, D. G. Higgins, and T. J. Gibson, CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Research, vol.22, issue.22, pp.4673-4680, 1994.
DOI : 10.1093/nar/22.22.4673

C. Bosc, J. D. Cronk, F. Pirollet, D. M. Watterson, J. Haiech et al., Cloning, expression, and properties of the microtubule-stabilizing protein STOP., Proceedings of the National Academy of Sciences, vol.93, issue.5, pp.2125-2130, 1996.
DOI : 10.1073/pnas.93.5.2125

U. K. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.244, issue.5259, pp.680-685, 1970.
DOI : 10.1038/227680a0

A. Lieuvin, J. C. Labbé, M. Dorée, J. , and D. , Intrinsic microtubule stability in interphase cells, The Journal of Cell Biology, vol.124, issue.6, pp.985-996, 1994.
DOI : 10.1083/jcb.124.6.985

F. Pirollet, J. Derancourt, J. Haiech, D. Job, and R. L. Margolis, Calcium-calmodulin regulated effectors of microtubule stability in bovine brain, Biochemistry, vol.31, issue.37, pp.8849-8855, 1992.
DOI : 10.1021/bi00152a022

D. Masson and T. E. Kreis, Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells, The Journal of Cell Biology, vol.123, issue.2, pp.357-371, 1993.
DOI : 10.1083/jcb.123.2.357

R. Frank, Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support, Tetrahedron, vol.48, issue.42, pp.9217-9232, 1992.
DOI : 10.1016/S0040-4020(01)85612-X

D. Paolo, G. Lutjens, R. Pellier, V. Stimpson, S. A. Beuchat et al., Targeting of SCG10 to the Area of the Golgi Complex Is Mediated by Its NH2-terminal Region, Journal of Biological Chemistry, vol.272, issue.8, pp.5175-5182, 1997.
DOI : 10.1074/jbc.272.8.5175

M. D. Resh, Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1451, issue.1, pp.1-16, 1999.
DOI : 10.1016/S0167-4889(99)00075-0

E. M. Ross, Protein Modification: Palmitoylation in G-protein signaling pathways, Current Biology, vol.5, issue.2, pp.107-109, 1995.
DOI : 10.1016/S0960-9822(95)00026-1

S. M. Mumby, Reversible palmitoylation of signaling proteins, Current Opinion in Cell Biology, vol.9, issue.2, pp.148-154, 1997.
DOI : 10.1016/S0955-0674(97)80056-7

D. Job, E. H. Fischer, and R. L. Margolis, Rapid disassembly of cold-stable microtubules by calmodulin., Proceedings of the National Academy of Sciences, vol.78, issue.8, pp.4679-4682, 1981.
DOI : 10.1073/pnas.78.8.4679

K. Huang and A. Husseini, Modulation of neuronal protein trafficking and function by palmitoylation, Current Opinion in Neurobiology, vol.15, issue.5, pp.527-535, 2005.
DOI : 10.1016/j.conb.2005.08.001

*. We, A. Schweitzer, and N. , Collomb for their technical assistance; Y. Saoudi for help in imaging

J. Fauré, J. Brocard, and J. C. , Deloulme for their helpful discussions. This work was supported in part by grants from La Ligue Nationale

. Golgi, GM130 mAb) and SL21 (SL21 polyclonal antibody 3315) Bar, ) and 16 µm (B), p.20