Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. - Archive ouverte HAL Access content directly
Journal Articles AJP - Endocrinology and Metabolism Year : 2007

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.

(1, 2, 3) , (3) , (3) , (3) , (3) , (3) , (2) , (3, 4) , (3) , (5) , (3) , (1, 3)
1
2
3
4
5

Abstract

Individuals born with a low birth weight (LBW) have an increased prevalence of type 2 diabetes, but the mechanisms responsible for this association are unknown. Given the important role of insulin resistance in the pathogenesis of type 2 diabetes, we examined insulin sensitivity in a rat model of LBW due to intrauterine fetal stress. During the last 7 days of gestation, rat dams were treated with dexamethasone and insulin sensitivity was assessed in the LBW offspring by a hyperinsulinemic euglycemic clamp. The LBW group had liver-specific insulin resistance associated with increased levels of PEPCK expression. These changes were associated with pituitary hyperplasia of the ACTH-secreting cells, increased morning plasma ACTH concentrations, elevated corticosterone secretion during restraint stress, and an approximately 70% increase in 24-h urine corticosterone excretion. These data support the hypothesis that prenatal stress can result in chronic hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in increased plasma corticosterone concentrations, upregulation of hepatic gluconeogenesis, and hepatic insulin resistance.
Fichier principal
Vignette du fichier
Buhl_et_al_HAL.pdf (268.03 Ko) Télécharger le fichier
Vignette du fichier
inserm-00379890_edited.pdf (1.17 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00379890 , version 1 (10-09-2009)

Identifiers

Cite

Esben S. Buhl, Susanne Neschen, Shin Yonemitsu, Joerg Rossbacher, Dongyan Zhang, et al.. Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.. AJP - Endocrinology and Metabolism, 2007, 293 (5), pp.E1451-8. ⟨10.1152/ajpendo.00356.2007⟩. ⟨inserm-00379890⟩

Collections

INSERM UGA
112 View
486 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More