[Role of P/Q calcium channel in familial hemiplegic migraine] - Archive ouverte HAL Access content directly
Journal Articles médecine/sciences Year : 2007

[Role of P/Q calcium channel in familial hemiplegic migraine]

(1) , (2) , (1)
1
2

Abstract

Voltage-dependent calcium channels constitute one of the main pathways of calcium entry into neurons. They are the principal actors of synaptic transmission by controlling the release of neurotransmitters. They also contribute to numerous other cell functions, such as gene expression or synaptogenesis. These channels, by their essential cell functions, are at the origin of numerous channelopathies resulting from mutations of the genes encoding their different subunits. Familial Hemiplegic Migraine (FHM) represents one such example of these channelopathies. In this human disease, genetic studies have demonstrated the implication of the CACNA1A gene in a type 1 form of FHM. This gene encodes for the Ca(v)2.1 subunit of P/Q calcium channels and is the target of numerous mutations affecting the properties of channel activity. The question on how discrete mutations of this gene are able to alter the activity of the channel and contribute to the physiopathology of FHM remains an open question. The functional characterization of mutated channels in various heterologous expression systems, as well as in vivo in an animal model, provides a molecular scheme of the physiopathology of FHM in which neurons, astrocytes and blood circulation act in concert.
Fichier principal
Vignette du fichier
Weiss_et_al_Manuscrit_-_revision.pdf (200.33 Ko) Télécharger le fichier
Vignette du fichier
Weiss_et_al_Figure_1.jpg (228.49 Ko) Télécharger le fichier
Vignette du fichier
Weiss_et_al_Figure_2.jpg (1.41 Mo) Télécharger le fichier
Vignette du fichier
Weiss_et_al_Figure_3.jpg (1.02 Mo) Télécharger le fichier
Vignette du fichier
Weiss_et_al_Figure_4.jpg (996.79 Ko) Télécharger le fichier
Vignette du fichier
Weiss_et_al_Figure_5.jpg (1.14 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Format : Other
Format : Other
Format : Other
Format : Other
Format : Other
Loading...

Dates and versions

inserm-00378047 , version 1 (05-05-2009)

Identifiers

  • HAL Id : inserm-00378047 , version 1
  • PUBMED : 17212932

Cite

Norbert Weiss, Elisabeth Tournier-Lasserve, Michel de Waard. [Role of P/Q calcium channel in familial hemiplegic migraine]. médecine/sciences, 2007, 23 (1), pp.53-63. ⟨inserm-00378047⟩
751 View
1950 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More