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Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy.

Abstract : This paper summarizes recent data from the literature suggesting that transforming growth factor-beta (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection.
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https://www.hal.inserm.fr/inserm-00376346
Contributor : Jean-Jacques Feige <>
Submitted on : Friday, April 17, 2009 - 1:40:21 PM
Last modification on : Monday, October 8, 2018 - 5:44:08 PM

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Tania Araújo-Jorge, Mariana Waghabi, Maria de Nazaré C Soeiro, Michelle Keramidas, Sabine Bailly, et al.. Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy.. Cytokine & Growth Factor Reviews, 2008, 19 (5-6), pp.405-13. ⟨10.1016/j.cytogfr.2008.08.002⟩. ⟨inserm-00376346⟩

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