Skip to Main content Skip to Navigation
Journal articles

SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.

Abstract : The antiinflammatory cytokine transforming growth factor beta (TGF-beta) plays an important role in Chagas disease, a parasitic infection caused by the protozoan Trypanosoma cruzi. In the present study, we show that SB-431542, an inhibitor of the TGF-beta type I receptor (ALK5), inhibits T. cruzi-induced activation of the TGF-beta pathway in epithelial cells and in cardiomyocytes. Further, we demonstrate that addition of SB-431542 greatly reduces cardiomyocyte invasion by T. cruzi. Finally, SB-431542 treatment significantly reduces the number of parasites per infected cell and trypomastigote differentiation and release. Taken together, these data further confirm the major role of the TGF-beta signaling pathway in both T. cruzi infection and T. cruzi cell cycle completion. Our present data demonstrate that small inhibitors of the TGF-beta signaling pathway might be potential pharmacological tools for the treatment of Chagas disease.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00376225
Contributor : Jean-Jacques Feige <>
Submitted on : Friday, April 17, 2009 - 9:27:38 AM
Last modification on : Monday, May 18, 2020 - 4:50:33 PM

Links full text

Identifiers

Collections

CEA | UGA | RIIP

Citation

Waghabi Mariana, Michelle Keramidas, Claudia Calvet, Marcos Meuser, Maria de Nazaré C Soeiro, et al.. SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (8), pp.2905-10. ⟨10.1128/AAC.00022-07⟩. ⟨inserm-00376225⟩

Share

Metrics

Record views

173