Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2007

Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis.

Résumé

Aberrant expression of G protein-coupled receptors (GPCR) in the adrenal cortex is observed in some cases of ACTH-independent macronodular adrenal hyperplasias and adenomas associated with Cushing syndrome (CS). Although there is clinical evidence for the implication of these receptors in abnormal regulation of cortisol secretion, whether this aberrant expression also directly causes the development of a benign adrenocortical tumor is an open question. Cell transplantation provides a way to study genes that may be important in human tumor development. The system we developed uses genetically modified adrenocortical cells transplanted into adrenalectomized immunodeficient mice, which form a functional tissue structure. We observed that enforcing expression of the gastric inhibitory polypeptide (GIP) receptor or the luteinizing hormone (LH) receptor genes (taken as canonical examples of aberrantly expressed GPCRs) in adrenocortical cells resulted in the formation of hyperplastic tissues and the development of Cushing syndrome features in transplanted mice.

Dates et versions

inserm-00376122 , version 1 (16-04-2009)

Identifiants

Citer

Tânia L. Mazzuco, Olivier Chabre, Jean-Jacques Feige, Michaël Thomas. Aberrant GPCR expression is a sufficient genetic event to trigger adrenocortical tumorigenesis.. Molecular and Cellular Endocrinology, 2007, 265-266, pp.23-8. ⟨10.1016/j.mce.2006.12.034⟩. ⟨inserm-00376122⟩

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