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Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.

Abstract : The thymus continuously produces T lymphocytes that contribute to the maintenance of the peripheral T cell pool. Since peripheral recirculating T cells represent a very minor population among total thymocytes in normal animals, the relationship between the thymus and secondary lymphoid organs is generally considered unidirectional. Recently, several reports have described the presence of recirculating T cells in the thymus, raising issues regarding their possible function. In this article, we show that the niche for recirculating T cells in the thymus, i.e., their absolute number, is the same in lymphopenic and normal mice. Using a novel combination of TCR-transgenic mice in which the ligand necessary for positive selection of host T cells is only expressed by transferred donor T cells, we show that mature T cells recirculating back to the thymus can mediate positive selection.
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Submitted on : Wednesday, April 29, 2009 - 4:01:55 PM
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  • HAL Id : inserm-00375635, version 1
  • PUBMED : 18606674



Jörg Kirberg, Nabil Bosco, Jean-Christophe Deloulme, Rhodri Ceredig, Fabien Agenès. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 181 (2), pp.1207-14. ⟨inserm-00375635⟩



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