Tau as a biomarker of neurodegenerative diseases. - Archive ouverte HAL Access content directly
Journal Articles Biomarkers in Medicine Year : 2008

Tau as a biomarker of neurodegenerative diseases.

(1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (2) , (1)
1
2

Abstract

The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including Alzheimer's disease. The molecular diversity of Tau is very useful when analyzing it in the brain or in the peripheral fluids. Immunohistochemical and biochemical characterization of Tau aggregates in the brain allows the postmortem classification and differential diagnosis of tauopathies. As peripheral biomarkers of Alzheimer's disease in the cerebrospinal fluid, Tau proteins are now validated for diagnosis and predictive purposes. For the future, the detailed characterization of Tau in the brain and in peripheral fluids will lead to novel promising biomarkers for differential diagnosis of dementia and monitoring of therapeutics.
Fichier principal
Vignette du fichier
inserm-00375314_edited.pdf (711.94 Ko) Télécharger le fichier
Vignette du fichier
HAL_Schraen.pdf (13.09 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00375314 , version 1 (14-04-2009)

Identifiers

Cite

Susanna Schraen-Maschke, Nicolas Sergeant, Claire-Marie Dhaenens, Stephanie Bombois, Vincent Deramecourt, et al.. Tau as a biomarker of neurodegenerative diseases.. Biomarkers in Medicine, 2008, 2 (4), pp.363-84. ⟨10.2217/17520363.2.4.363⟩. ⟨inserm-00375314⟩
178 View
858 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More