E. Braunwald and M. A. Pfeffer, Ventricular enlargement and remodeling following acute myocardial infarction: mechanisms and management. The American journal of cardiology 68 The immune system and cardiac repair. Pharmacol Res cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat, The Journal of biological chemistry, vol.280, pp.18881-18890, 1991.
DOI : 10.1016/0002-9149(91)90255-j

B. Mamar, F. Rocaries, M. Best-belpomme, T. Levade, C. Pavoine et al., N-acetylcysteine prevents the deleterious effect of tumor necrosis factor(alpha ) on calcium transients and contraction in adult rat cardiomyocytes, Circulation, vol.109, pp.406-411, 2004.

K. Shivakumar, S. J. Sollott, M. Sangeetha, S. Sapna, B. Ziman et al., Paracrine effects of hypoxic fibroblast-derived factors on the MPT-ROS threshold and viability of adult rat cardiac myocytes, AJP: Heart and Circulatory Physiology, vol.294, issue.6, pp.2653-2658, 2008.
DOI : 10.1152/ajpheart.91443.2007

D. M. Yellon and D. J. Hausenloy, Myocardial Reperfusion Injury, New England Journal of Medicine, vol.357, issue.11, pp.1121-1135, 2007.
DOI : 10.1056/NEJMra071667

R. A. Gottlieb and R. L. Engler, Apoptosis in Myocardial Ischemia-Reperfusion, Annals of the New York Academy of Sciences, vol.17, issue.1 HEART IN STRE, pp.412-426, 1999.
DOI : 10.1023/A:1027387301845

H. Yaoita, K. Ogawa, K. Maehara, and Y. Maruyama, Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor, Circulation, vol.97, issue.3, pp.276-281, 1998.
DOI : 10.1161/01.CIR.97.3.276

G. Condorelli, R. Roncarati, J. Ross, . Jr, A. Pisani et al., Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function, Proceedings of the National Academy of Sciences of the United States of America 98, pp.9977-9982, 2001.
DOI : 10.1073/pnas.161120198

S. Donath, P. Li, C. Willenbockel, N. Al-saadi, V. Gross et al., Apoptosis Repressor With Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress, Circulation, vol.113, issue.9, pp.1203-1212, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.576785

D. L. Mann, J. J. Mcmurray, M. Packer, K. Swedberg, J. S. Borer et al., Targeted Anticytokine Therapy in Patients With Chronic Heart Failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL), Circulation, vol.109, issue.13, pp.1594-1602, 2004.
DOI : 10.1161/01.CIR.0000124490.27666.B2

S. Sarkar, E. Vellaichamy, D. Young, and S. Sen, Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes, AJP: Heart and Circulatory Physiology, vol.287, issue.1, pp.107-117, 2004.
DOI : 10.1152/ajpheart.00763.2003

F. Frangogiannis and N. G. , Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling, Circulation, vol.116, pp.2127-2138, 2007.

M. Ikeuchi, H. Tsutsui, T. Shiomi, H. Matsusaka, S. Matsushima et al., Inhibition of TGF-? signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction, Cardiovascular Research, vol.64, issue.3, pp.526-535, 2004.
DOI : 10.1016/j.cardiores.2004.07.017

S. Lotersztajn, F. Teixeira-clerc, B. Julien, V. Deveaux, Y. Ichigotani et al., CB2 receptors as new therapeutic targets for liver diseases, British Journal of Pharmacology, vol.171, issue.2, pp.286-289, 2008.
DOI : 10.1038/sj.bjp.0707511

A. Mallat, S. Lotersztajn, F. Teixeira-clerc, B. Julien, P. Grenard et al., Endocannabinoids and Liver Disease. I. Endocannabinoids and their receptors in the liver, AJP: Gastrointestinal and Liver Physiology, vol.294, issue.1, pp.9-12, 2006.
DOI : 10.1152/ajpgi.00467.2007

P. Mukhopadhyay, S. Batkai, M. Rajesh, N. Czifra, J. Harvey-white et al., Pharmacological Inhibition of CB1Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity, Journal of the American College of Cardiology, vol.50, issue.6, pp.528-536, 2007.
DOI : 10.1016/j.jacc.2007.03.057

S. Batkai, P. Mukhopadhyay, J. Harvey-white, R. Kechrid, P. Pacher et al., Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats, AJP: Heart and Circulatory Physiology, vol.293, issue.3, pp.1689-1695, 2007.
DOI : 10.1152/ajpheart.00538.2007

S. A. Gaskari, H. Liu, L. Moezi, Y. Li, S. K. Baik et al., Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats, British Journal of Pharmacology, vol.223, issue.3, pp.315-323, 2005.
DOI : 10.1038/sj.bjp.0706331

S. Batkai, M. Rajesh, P. Mukhopadhyay, G. Hasko, L. Liaudet et al., Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase, AJP: Heart and Circulatory Physiology, vol.293, issue.2, pp.909-918, 2007.
DOI : 10.1152/ajpheart.00373.2007

S. Steffens, N. R. Veillard, C. Arnaud, G. Pelli, F. Burger et al., Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice, Nature, vol.24, issue.7034, pp.782-786, 2005.
DOI : 10.1016/S0379-0738(01)00538-2

A. Anatomic, functional and echocardiographic parameters of sham or 4w-IR hearts. BW indicates body weight; HW, heart weight; TL, tibia length; LVEDV, left ventricular enddiastolic volume; LVESV left ventricular end-systolic volume, EF, ejection fraction; SBP, systolic blood pressure

D. Wt, Sirius red staining with representative labelling (left) and quantitative analysis (right) of septal and scar collagen. * p<0.05 vs sham and § p<0, pp.5-9