Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa. - Archive ouverte HAL Access content directly
Journal Articles AIDS Year : 2009

Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa.

(1) , (2) , (3) , (4) , (5) , (6) , (7) , (6) , (1) , (7) , (2, 4, 6)
1
2
3
4
5
6
7

Abstract

OBJECTIVES: A synergy between HIV and herpes simplex virus type 2 (HSV-2) infections has been reported in observational studies. The objectives of this study were to estimate the per-sex-act female-to-male transmission probabilities (FtoMTPs) of HIV and HSV-2, the effect of each infection on the FtoMTP of the other and the effect of male circumcision on these FtoMTPs. DESIGN: We used longitudinal data collected during the male circumcision trial conducted in Orange Farm (South Africa). METHODS: Results were obtained by specific mathematical modeling of HIV and HSV-2 statuses of the men as functions of their sexual behavior and male circumcision status. The model took into account an estimation of the HIV and HSV-2 statuses of each of their female partners. Confidence intervals (CI) were estimated using a bootstrap resampling method. RESULTS: The HIV and HSV-2 FtoMTPs, during an unprotected sexual contact for an uncircumcised male in the absence of the other virus in both partners, were 0.0047 (95% CI: 0.0014-0.017) and 0.0067 (95% CI: 0.0028-0.014), respectively. HSV-2 in either partner increased HIV FtoMTP with a relative risk (RR) of 3.0 (95% CI: 1.01-7.3). Conversely, HIV in either partner increased HSV-2 FtoMTP (RR= 2.5; 95% CI: 1.1- 6.3). Male circumcision significantly decreased these probabilities with RRs of 0.24 (95% CI: 0.11-0.44) and 0.59 (95% CI: 0.36-0.91), respectively. CONCLUSION: This study gave the first estimates of HSV-2 per-sex-act FtoMTPs in Africa. It demonstrated a synergy between HIV and HSV-2 infections and a protective effect of male circumcision on HSV-2 acquisition by males.
Fichier principal
Vignette du fichier
Mahiane_AIDS.pdf (180.38 Ko) Télécharger le fichier
Vignette du fichier
inserm-00371763_edited.pdf (139.35 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00371763 , version 1 (01-02-2010)

Identifiers

  • HAL Id : inserm-00371763 , version 1
  • PUBMED : 19198042

Cite

Séverin-Guy Mahiane, Camille Legeai, Dirk Taljaard, Aurélien Latouche, Adrian Puren, et al.. Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa.: HSV-2, HIV and male circumcision. AIDS, 2009, 23 (3), pp.377-383. ⟨inserm-00371763⟩
253 View
740 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More