Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis. - Archive ouverte HAL Access content directly
Journal Articles Multiple Sclerosis Journal Year : 2009

Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.

(1) , (2) , (1) , (3) , (3) , (2) , (4) , (1)
1
2
3
4

Abstract

BackgroundHuman endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients.Objective and methodsWe analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-alpha (P < 0.05) and interferon-gamma (P < 0.004) in AMS patients and of interleukin-10 (P < 0.05), an inflammation-dampening cytokine, in SMS individuals.ConclusionsThese data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.

Dates and versions

inserm-00371200 , version 1 (26-03-2009)

Identifiers

Cite

Marina Saresella, Alexandre Rolland, Ivana Marventano, Rosella Cavarretta, Domenico Caputo, et al.. Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.. Multiple Sclerosis Journal, 2009, epub ahead of print. ⟨10.1177/1352458508100840⟩. ⟨inserm-00371200⟩
88 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More