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Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.

Abstract : BackgroundHuman endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients.Objective and methodsWe analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-alpha (P < 0.05) and interferon-gamma (P < 0.004) in AMS patients and of interleukin-10 (P < 0.05), an inflammation-dampening cytokine, in SMS individuals.ConclusionsThese data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.
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https://www.hal.inserm.fr/inserm-00371200
Contributor : Patrice Marche <>
Submitted on : Thursday, March 26, 2009 - 6:54:45 PM
Last modification on : Friday, November 6, 2020 - 3:46:04 AM

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Marina Saresella, Alexandre Rolland, Ivana Marventano, Rosella Cavarretta, Domenico Caputo, et al.. Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.. Multiple Sclerosis Journal, SAGE Publications, 2009, epub ahead of print. ⟨10.1177/1352458508100840⟩. ⟨inserm-00371200⟩

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