R. Ackermann, C. Mulrow, and G. Ramirez, Garlic Shows Promise for Improving Some Cardiovascular Risk Factors, Archives of Internal Medicine, vol.161, issue.6, pp.813-837, 2001.
DOI : 10.1001/archinte.161.6.813

S. Adachi, L. Leoni, and D. Carson, Apoptosis Induced by Molecular Targeting Therapy in Hematological Malignancies, Acta Haematologica, vol.111, issue.1-2, pp.107-130, 2004.
DOI : 10.1159/000074490

H. Amagase, Clarifying the real bioactive constituents of garlic, J Nutr, vol.136, pp.716-741, 2006.

I. Arnault, J. Christides, and N. Mandon, High-performance ion-pair chromatography method for simultaneous analysis of alliin, deoxyalliin, allicin and dipeptide precursors in garlic products using multiple mass spectrometry and UV detection, Journal of Chromatography A, vol.991, issue.1, pp.69-75, 2003.
DOI : 10.1016/S0021-9673(03)00214-0

J. Auger, F. Lalau-keraly, and C. Belinsky, Thiosulfinates in vapor phase are stable and they can persist in the environment of Allium, Chemosphere, vol.21, issue.7, pp.837-880, 1990.
DOI : 10.1016/0045-6535(90)90165-P

P. Badol, M. David-dufi-lho, and J. Auger, Thiosulfinates modulate platelet activation by reaction with surface free sulfhydryls and internal thiol-containing proteins, Platelets, vol.84, issue.7, pp.481-90, 2007.
DOI : 10.1042/bj20030610

URL : https://hal.archives-ouvertes.fr/hal-00196417

N. Barber, L. Belov, and R. Christopherson, All-trans retinoic acid induces different immunophenotypic changes on human HL60 and NB4 myeloid leukaemias, Leukemia Research, vol.32, issue.2, pp.315-337, 2008.
DOI : 10.1016/j.leukres.2007.04.013

B. Baumgartner, M. Weber, and M. Quirling, Increased I??B kinase activity is associated with activated NF-??B in acute myeloid blasts, Leukemia, vol.16, issue.10, pp.2062-71, 2002.
DOI : 10.1038/sj.leu.2402641

. Merhi, Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons, Leukemia, vol.16, pp.791-799, 2002.

G. Bergh, M. Ehinger, and I. Olsson, Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells, Blood, vol.94, pp.1971-1979, 1999.

C. Borek, Garlic reduces dementia and heart-disease risk, J Nutr, vol.136, pp.810-812, 2006.

T. Braun, G. Carvalho, and C. Fabre, Targeting NF-??B in hematologic malignancies, Cell Death and Differentiation, vol.457, issue.5, pp.748-58, 2006.
DOI : 10.1084/JEM.191.6.977

D. Cilloni, G. Martinelli, and F. Messa, Nuclear factor ??B as a target for new drug development in myeloid malignancies, Haematologica, vol.92, issue.9, pp.1224-1233, 2007.
DOI : 10.3324/haematol.11199

S. Collins, The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression, Blood, vol.70, pp.1233-1277, 1987.

D. Benedetti, F. Falk, L. Ellingsworth, and L. , Synergy between transforming growth factor-beta and tumor necrosis factor-alpha in the induction of monocytic differentiation of human leukemic cell lines, Blood, vol.75, pp.626-658, 1990.

E. Deryugina and J. Quigley, Matrix metalloproteinases and tumor metastasis, Cancer and Metastasis Reviews, vol.60, issue.Pt 1, pp.9-34, 2006.
DOI : 10.1007/s10555-006-7886-9

H. Drexler and Y. Matsuo, Guidelines for the characterization and publication of human malignant hematopoietic cell lines, Leukemia, vol.13, issue.6, pp.835-877, 1999.
DOI : 10.1038/sj.leu.2401428

H. Drexler, H. Quentmeier, and R. Macleod, Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations, Leukemia, vol.18, issue.2, pp.227-259, 2004.
DOI : 10.1038/sj.leu.2403236

F. Ferrara, F. Fazi, and A. Bianchini, Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia, Cancer Res, vol.61, pp.2-7, 2001.

W. Fiedler, U. Graeven, and S. Ergun, Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia, Blood, vol.89, pp.1870-1875, 1997.

A. Herman-antosiewicz and S. Singh, Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.555, issue.1-2, pp.121-152, 2004.
DOI : 10.1016/j.mrfmmm.2004.04.016

G. Hodge, S. Davis, and M. Rice, Garlic compounds selectively kill childhood pre-B acute lymphoblastic leukemia cells in vitro without reducing T-cell function: Potential therapeutic use in the treatment of ALL, Biologics: Targets & Therapy, vol.1, pp.143-152, 2008.
DOI : 10.2147/BTT.S2465

T. Hosono, T. Fukao, and J. Ogihara, Diallyl Trisulfide Suppresses the Proliferation and Induces Apoptosis of Human Colon Cancer Cells through Oxidative Modification of ??-Tubulin, Journal of Biological Chemistry, vol.280, issue.50, pp.41487-93, 2005.
DOI : 10.1074/jbc.M507127200

K. Ippoushi, H. Itou, and K. Azuma, Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages, Life Sciences, vol.71, issue.4, pp.411-430, 2002.
DOI : 10.1016/S0024-3205(02)01685-5

J. Jurcic, S. Soignet, and A. Maslak, Diagnosis and treatment of acute promyelocytic leukemia, Current Oncology Reports, vol.20, issue.5, pp.337-381, 2007.
DOI : 10.1007/s11912-007-0045-9

R. Kamijo, K. Takeda, and M. Nagumo, Effects of combinations of transforming growth factor-beta 1 and tumor necrosis factor on induction of differentiation of human myelogenous leukemic cell lines, J Immunol, vol.144, pp.1311-1327, 1990.

H. Keiss, V. Dirsch, and T. Hartung, Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity, J Nutr, vol.133, pp.2171-2176, 2003.

A. Khanna-gupta, K. Kolibaba, and T. Zibello, NB4 cells show bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression, Blood, vol.84, pp.294-302, 1994.

F. Khanum, K. Anilakumar, and K. Viswanathan, Anticarcinogenic Properties of Garlic: A Review, Critical Reviews in Food Science and Nutrition, vol.58, issue.6, pp.479-88, 2004.
DOI : 10.1021/jf00015a002

Y. Kim, N. Abraham, and J. Lutton, Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3, Leukemia Research, vol.15, issue.6, pp.409-427, 1991.
DOI : 10.1016/0145-2126(91)90050-4

M. King and J. Rowe, Recent developments in acute myelogenous leukemia therapy, Oncologist, vol.12, issue.2, pp.14-21, 2007.

A. Kini, L. Peterson, and M. Tallman, Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid, Blood, vol.97, issue.12, pp.3919-3943, 2001.
DOI : 10.1182/blood.V97.12.3919

G. Klein, E. Vellenga, and M. Fraaije, The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia, Critical Reviews in Oncology/Hematology, vol.50, issue.2, pp.87-100, 2004.
DOI : 10.1016/j.critrevonc.2003.09.001

K. Kwon, S. Yoo, and D. Ryu, Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells11Abbreviations: Ac-DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp-CHO (aldehyde); Ac-DEVD-AFC, N-acetyl-Asp-Glu-Val-Asp-AFC (7-amino-4-trifluoromethyl-coumaine); Ac-YVAD-CHO, N-acetyl-Tyr-Val-Ala-Asp-CHO (aldehyde); CAD, caspase-activated deoxyribonuclease; CM-H2DCFDA, 5-(and -6)-chloromethyl-2???,7???-dichlorodihydrofluorescein diacetate; DADS, diallyl disulfide; FACS, fluorescence-activated cell sorter; FITC, fluorescein isothiocyanate; ICAD, inhibitor of caspase-activated deoxyribonuclease; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetylcysteine; PARP, poly(ADP-ribose) polymerase; PI, propidium iodide; and ROI, reactive oxygen intermediate., Biochemical Pharmacology, vol.63, issue.1, pp.41-48, 2002.
DOI : 10.1016/S0006-2952(01)00860-7

M. Lanotte, V. Martin-thouvenin, and S. Najman, NB4, a maturation inducible cell line with t(15; 17) marker isolated from a human acute promyelocytic leukemia (M3), Blood, vol.77, pp.1080-1086, 1991.

V. Lanzotti, The analysis of onion and garlic, Journal of Chromatography A, vol.1112, issue.1-2, pp.3-22, 2006.
DOI : 10.1016/j.chroma.2005.12.016

L. Bon, A. Siess, and M. , Organosulfur compounds from Allium and the chemoprevention of cancer, Drug Metabol Drug Interact, vol.17, pp.51-79, 2000.

G. Leone, S. Sica, and M. Voso, Treatment of Acute Leukaemias with Monoclonal Antibodies: Current Status and Future Prospects, Cardiovascular & Hematological Agents in Medicinal Chemistry, vol.4, issue.1, pp.33-52, 2006.
DOI : 10.2174/187152506775268820

V. Longo, A. Vacca, and D. Ribatti, Imaging and angiogenesis in hematological malignancies, Leukemia, vol.21, issue.8, p.1605, 2007.
DOI : 10.1038/sj.leu.2404066

R. Lu and P. Pitha, Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7, Journal of Biological Chemistry, vol.276, issue.48, pp.45491-45497, 2001.
DOI : 10.1074/jbc.C100421200

L. Manzella, E. Conte, and G. Cocchiaro, Role of interferon regulatory factor 1 in monocyte/macrophage differentiation, European Journal of Immunology, vol.15, issue.9, pp.3009-3025, 1999.
DOI : 10.1002/(SICI)1521-4141(199909)29:09<3009::AID-IMMU3009>3.0.CO;2-H

S. Martin, C. Reutelingsperger, and A. Mcgahon, Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl, Journal of Experimental Medicine, vol.182, issue.5, pp.1545-56, 1995.
DOI : 10.1084/jem.182.5.1545

K. Mason, S. Juneja, and J. Szer, The immunophenotype of acute myeloid leukemia: is there a relationship with prognosis?, Blood Reviews, vol.20, issue.2, pp.71-82, 2006.
DOI : 10.1016/j.blre.2005.08.002

M. Mayo and A. Baldwin, The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance, Biochim Biophys Acta, vol.1470, pp.55-62, 2000.

K. Meyer, E. Ueberham, and R. Gebhardt, Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their Inhibitor TIMP-1 by cultured HUVEC cells, Cell Biology and Toxicology, vol.20, issue.4, pp.253-60, 2004.
DOI : 10.1023/B:CBTO.0000038463.55930.79

M. Milella, S. Kornblau, and Z. Estrov, Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia, Journal of Clinical Investigation, vol.108, issue.6, 2001.
DOI : 10.1172/JCI12807

J. Milner, Preclinical perspectives on garlic and cancer, J Nutr, vol.136, pp.827-858, 2006.

G. Opdenakker, I. Nelissen, and J. Van-damme, Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis, The Lancet Neurology, vol.2, issue.12, pp.747-56, 2003.
DOI : 10.1016/S1474-4422(03)00587-8

W. Parks, C. Wilson, and Y. Lopez-boado, Matrix metalloproteinases as modulators of inflammation and innate immunity, Nature Reviews Immunology, vol.158, issue.8, pp.617-646, 2004.
DOI : 10.1073/pnas.93.9.3942

J. Pinto and R. Rivlin, Antiproliferative effects of allium derivatives from garlic, J Nutr, vol.131, pp.1058-60, 2001.

L. Platanias, Map kinase signaling pathways and hematologic malignancies, Blood, vol.101, issue.>12, pp.4667-79, 2003.
DOI : 10.1182/blood-2002-12-3647

C. Plesa, Y. Chelghoum, and A. Plesa, Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia, Cancer, vol.103, issue.3, pp.572-80, 2008.
DOI : 10.1002/cncr.23219

R. Qi, F. Liao, and K. Inoue, Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca2+ mobilization without affecting inositol-1,4,5-trisphosphate (IP3) formation in activated platelets, Biochemical Pharmacology, vol.60, issue.10, pp.1475-83, 2000.
DOI : 10.1016/S0006-2952(00)00467-6

S. Rajkumar, R. Mesa, and A. Tefferi, A Review of Angiogenesis and Anti-Angiogenic Therapy in Hematologic Malignancies, Journal of Hematotherapy & Stem Cell Research, vol.11, issue.1, pp.33-47, 2002.
DOI : 10.1089/152581602753448522

F. Rendu, B. Brohard-bohn, and S. Pain, Thiosulfi nates inhibit platelet aggregation and microparticle shedding at a calpain-dependent step, Thromb Haemost, vol.86, pp.1284-91, 2001.

D. Ribatti, C. Scavelli, and A. Roccaro, Hematopoietic Cancer and Angiogenesis, Stem Cells and Development, vol.13, issue.5, pp.484-95, 2004.
DOI : 10.1089/scd.2004.13.484

D. Sawka-verhelle, L. Escoubet-lozach, and A. Fong, PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation, Journal of Biological Chemistry, vol.279, issue.17, pp.17772-84, 2004.
DOI : 10.1074/jbc.M311991200

P. Stordeur, L. Poulin, and L. Craciun, Cytokine mRNA quantification by real-time PCR, Journal of Immunological Methods, vol.259, issue.1-2, pp.55-64, 2002.
DOI : 10.1016/S0022-1759(01)00489-6

S. Sundaram and J. Milner, Diallyl disulfide induces apoptosis of human colon tumor cells, Carcinogenesis, vol.17, issue.4, pp.669-73, 1996.
DOI : 10.1093/carcin/17.4.669

S. Sundaram and J. Milner, Diallyl disulfide inhibits the proliferation of human tumor cells in culture, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1315, issue.1, pp.15-20, 1996.
DOI : 10.1016/0925-4439(95)00088-7

D. Thomas, F. Giles, and J. Cortes, Antiangiogenic Therapy in Leukemia, Acta Haematologica, vol.106, issue.4, pp.190-207, 2001.
DOI : 10.1159/000046616

X. Thomas and M. Elhamri, Tipifarnib in the treatment of acute myeloid leukemia, Biologics: Targets and Therapy, vol.1, pp.415-439, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00453233

I. Trayner, T. Bustorff, and A. Etches, Changes in antigen expression on differentiating HL60 cells treated with dimethylsulphoxide, all-trans retinoic acid, ??1,25-dihydroxyvitamin D3 or 12-O-tetradecanoyl phorbol-13-acetate, Leukemia Research, vol.22, issue.6, pp.537-584, 1998.
DOI : 10.1016/S0145-2126(98)00041-1

H. Watanabe, I. Nakanishi, and K. Yamashita, Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion, J Cell Sci, vol.104, pp.991-1000, 1993.

J. Westphal, R. Van-'t-hullenaar, and R. Peek, Angiogenic balance in human melanoma: Expression of VEGF, bFGF, IL???8, PDGF and angiostatin in relation to vascular density of xenografts in vivo, International Journal of Cancer, vol.86, issue.6, pp.768-76, 2000.
DOI : 10.1002/(SICI)1097-0215(20000615)86:6<768::AID-IJC3>3.3.CO;2-5

D. Xiao, J. Pinto, and G. Gundersen, Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells, Molecular Cancer Therapeutics, vol.4, issue.9, pp.1388-98, 2005.
DOI : 10.1158/1535-7163.MCT-05-0152

D. Xiao, J. Pinto, and J. Soh, Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation, Cancer Res, vol.63, pp.6825-6862, 2003.

D. Xiao and S. Singh, Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells, Carcinogenesis, vol.27, issue.3, pp.533-573, 2006.
DOI : 10.1093/carcin/bgi228

S. Zheng, H. Yang, and S. Zhang, Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention, Journal of Cellular Biochemistry, vol.336, issue.S27, pp.106-118, 1997.
DOI : 10.1002/(SICI)1097-4644(1997)27+<106::AID-JCB17>3.0.CO;2-L