[START domain-containing proteins: a review of their role in lipid transport and exchange]

Fifteen START domain-containing proteins exist in mammals. On the basis of their structural homology, this family is divided into several sub-families consisting mainly of non-vesicular intracellular lipid carriers. With the exception of the Thioesterase-START subfamily, the other subfamilies are represented among invertebrates. The START domain is always located in the C-terminus of the protein. It is a module of about 210 residues that binds lipids, including sterols. Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. The lipids or sterols bound by the remaining 7 START proteins are unknown. The START domain can be regarded as a lipid-exchange and/or a lipid-sensing domain. The START domain consists in a deep lipid-binding pocket--that shields the hydrophic ligand from the external aqueous environment--covered by a lid formed by a C-terminal alpha helix. Within the same subgroup, such as the sterols-carriers subgroup, different START domains have similar biochemical properties; however, their expression profile and their subcellular localization distinguish them and are critical for their different biological functions. START proteins act in a variety of distinct physiological processes, such as lipid transfer between intracellular compartments, lipid metabolism and modulation of signaling events. Mutation or misexpression of START proteins is linked to pathological processes, including genetic disorders, autoimmune diseases and cancers.

Mots clés

START Cholestérol phosphatidylcholine lipides

Domaines

Biochimie, Biologie Moléculaire

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Figure_3.pdf (8.9 Mo)

Figure_1.pdf (2.7 Mo)

Figure_2.pdf (1.93 Mo)

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Figure_5.pdf (453.59 Ko)

START_Revue_MS.pdf (153.06 Ko)

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Tableau_II.pdf (161.5 Ko)

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https://inserm.hal.science/inserm-00370089

Soumis le : mercredi 29 juillet 2009-07:00:03

Dernière modification le : lundi 11 mars 2024-10:38:22

Archivage à long terme le : jeudi 10 juin 2010-18:14:13

Dates et versions

inserm-00370089 , version 1 (29-07-2009)

Identifiants

HAL Id : inserm-00370089 , version 1
PUBMED : 19239851

Citer

Fabien Alpy, François Legueux, Laurent Bianchetti, Catherine Tomasetto. [START domain-containing proteins: a review of their role in lipid transport and exchange]. Médecine/Sciences, 2009, 25 (2), pp.181-91. ⟨inserm-00370089⟩

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