Skip to Main content Skip to Navigation
Journal articles

APRIL is overexpressed in cancer: link with tumor progression.

Abstract : ABSTRACT: BACKGROUND: BAFF and APRIL share two receptors - TACI and BCMA - and BAFF binds to a third receptor, BAFF-R. Increased expression of BAFF and APRIL is noted in hematological malignancies. BAFF and APRIL are essential for the survival of normal and malignant B lymphocytes, and altered expression of BAFF or APRIL or of their receptors (BCMA, TACI, or BAFF-R) have been reported in various B-cell malignancies including B-cell non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's lymphoma, multiple myeloma, and Waldenstrom's macroglobulinemia. METHODS: We compared the expression of BAFF, APRIL, TACI and BAFF-R gene expression in 40 human tumor types - brain, epithelial, lymphoid, germ cells - to that of their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray database. RESULTS: We found significant overexpression of TACI in multiple myeloma and thyroid carcinoma and an association between TACI expression and prognosis in lymphoma. Furthermore, BAFF and APRIL are overexpressed in many cancers and we show that APRIL expression is associated with tumor progression. We also found overexpression of at least one proteoglycan with heparan sulfate chains (HS), which are coreceptors for APRIL and TACI, in tumors where APRIL is either overexpressed or is a prognostic factor. APRIL could induce survival or proliferation directly through HS proteoglycans. CONCLUSION: Taken together, these data suggest that APRIL is a potential prognostic factor for a large array of malignancies.
Document type :
Journal articles
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00369505
Contributor : Monique Frei <>
Submitted on : Friday, March 20, 2009 - 10:32:36 AM
Last modification on : Friday, May 15, 2020 - 12:22:03 PM
Long-term archiving on: : Thursday, June 10, 2010 - 5:33:08 PM

File

HAL_inserm.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Jérôme Moreaux, Jean-Luc Veyrune, John de Vos, Bernard Klein. APRIL is overexpressed in cancer: link with tumor progression.. BMC Cancer, BioMed Central, 2009, 9 (1), pp.83. ⟨10.1186/1471-2407-9-83⟩. ⟨inserm-00369505⟩

Share

Metrics

Record views

418

Files downloads

1093