X. Chen, E. Sievers, Y. Hou, R. Park, M. Tohme et al., Integrin ????3-Targeted Imaging of Lung Cancer, Neoplasia, vol.7, issue.3, pp.271-279, 2005.
DOI : 10.1593/neo.04538

T. Sato, K. Konishi, H. Kimura, K. Maeda, K. Yabushita et al., Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma, Anticancer Res, vol.21, pp.643-647, 2001.

R. Seftor, . Seftor, . Ea, K. Gehlsen, . Stetler-stevenson et al., Role of the alpha v beta 3 integrin in human melanoma cell invasion., Proceedings of the National Academy of Sciences, vol.89, issue.5, pp.1557-1561, 1992.
DOI : 10.1073/pnas.89.5.1557

C. Gladson, . Cheresh, and . Da, Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells., Journal of Clinical Investigation, vol.88, issue.6, pp.1924-1932, 1991.
DOI : 10.1172/JCI115516

M. Rolli, E. Fransvea, J. Pilch, A. Saven, and . Felding-habermann, Activated integrin ??v??3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells, Proceedings of the National Academy of Sciences, vol.100, issue.16, pp.9482-9487, 2003.
DOI : 10.1073/pnas.1633689100

R. Hynes, Integrins, Cell, vol.110, issue.6, pp.673-687, 2002.
DOI : 10.1016/S0092-8674(02)00971-6

D. Calderwood, Integrin activation, Journal of Cell Science, vol.117, issue.5, pp.657-666, 2004.
DOI : 10.1242/jcs.01014

M. Ginsberg and A. Partridge, Integrin regulation, Current Opinion in Cell Biology, vol.17, issue.5, pp.509-516, 2005.
DOI : 10.1016/j.ceb.2005.08.010

C. Cluzel, F. Saltel, J. Lussi, F. Paulhe, . Imhof et al., The mechanisms and dynamics of ??v??3 integrin clustering in living cells, The Journal of Cell Biology, vol.75, issue.2, pp.383-392, 2005.
DOI : 10.1242/jcs.00792

URL : https://hal.archives-ouvertes.fr/hal-00314515

E. Garanger, D. Boturyn, and P. Dumy, Tumor Targeting with RGD Peptide Ligands-Design of New Molecular Conjugates for Imaging and Therapy of Cancers, Anti-Cancer Agents in Medicinal Chemistry, vol.7, issue.5, pp.552-558, 2007.
DOI : 10.2174/187152007781668706

J. Gestwicki, . Cairo, . Cw, L. Strong, K. Oetjen et al., Influencing Receptor???Ligand Binding Mechanisms with Multivalent Ligand Architecture, Journal of the American Chemical Society, vol.124, issue.50, pp.14922-14933, 2002.
DOI : 10.1021/ja027184x

K. Temming, R. Schiffelers, G. Molema, and K. , RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature, Drug Resistance Updates, vol.8, issue.6, pp.381-402, 2005.
DOI : 10.1016/j.drup.2005.10.002

S. Foillard, . Jin, . Zh, E. Garanger, D. Boturyn et al., Synthesis and Biological Characterisation of Targeted Pro-Apoptotic Peptide, ChemBioChem, vol.4, issue.14, pp.2326-2332, 2008.
DOI : 10.1002/cbic.200800327

URL : https://hal.archives-ouvertes.fr/inserm-00314521

Z. Jin, V. Josserand, J. Razkin, E. Garanger, D. Boturyn et al., Noninvasive optical imaging of ovarian metastases using Cy5-labeled RAFT-c(-RGDfK-)4, Mol Imaging, vol.5, pp.188-197, 2006.

Z. Jin, V. Josserand, S. Foillard, D. Boturyn, P. Dumy et al., In vivo optical imaging of integrin ??V-??3 in mice using multivalent or monovalent cRGD targeting vectors, Molecular Cancer, vol.6, issue.1, pp.41-57, 2007.
DOI : 10.1186/1476-4598-6-41

L. Sancey, V. Ardisson, . Riou, . Lm, M. Ahmadi et al., In vivo imaging of tumour angiogenesis in mice with the ??v??3 integrin-targeted tracer 99mTc-RAFT-RGD, European Journal of Nuclear Medicine and Molecular Imaging, vol.18, issue.Pt 19, pp.2037-2047, 2007.
DOI : 10.1007/s00259-007-0497-z

URL : https://hal.archives-ouvertes.fr/inserm-00176669

E. Garanger, D. Boturyn, Z. Jin, P. Dumy, M. Favrot et al., New Multifunctional Molecular Conjugate Vector for Targeting, Imaging, and Therapy of Tumors, Molecular Therapy, vol.12, issue.6, pp.1168-1175, 2005.
DOI : 10.1016/j.ymthe.2005.06.095

D. Cheresh and J. Harper, Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130- kDa alpha subunit, J Biol Chem, vol.262, pp.1434-1437, 1987.

S. Dedhar, E. Ruoslahti, . Pierschbacher, and . Md, A cell surface receptor complex for collagen type I recognizes the Arg- Gly-Asp sequence, The Journal of Cell Biology, vol.104, issue.3, pp.585-593, 1987.
DOI : 10.1083/jcb.104.3.585

R. Schiffelers, A. Ansari, J. Xu, Q. Zhou, Q. Tang et al., Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle, Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD, pp.149-170, 2004.
DOI : 10.1093/nar/gnh140

URL : http://doi.org/10.1093/nar/gnh140

H. Ellerby, W. Arap, . Ellerby, . Lm, R. Kain et al., Anti-cancer activity of targeted pro-apoptotic peptides, Nat Med, vol.5, pp.1032-1038, 1999.

S. Castel, R. Pagan, F. Mitjans, J. Piulats, S. Goodman et al., RGD Peptides and Monoclonal Antibodies, Antagonists of ??v-Integrin, Enter the Cells by Independent Endocytic Pathways, Laboratory Investigation, vol.92, issue.12, pp.1615-1626, 2001.
DOI : 10.1097/00002030-199710000-00005

A. Schraa, R. Kok, . Berendsen, . Ad, . Moorlag et al., Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting, Journal of Controlled Release, vol.83, issue.2, pp.241-251, 2002.
DOI : 10.1016/S0168-3659(02)00206-7

T. Pellinen and I. , Integrin traffic, Journal of Cell Science, vol.119, issue.18, pp.3723-3731, 2006.
DOI : 10.1242/jcs.03216

URL : http://jcs.biologists.org/cgi/content/short/119/18/3723

J. Pizarro-cerda and P. Cossart, Bacterial Adhesion and Entry into Host Cells, Cell, vol.124, issue.4, pp.715-727, 2006.
DOI : 10.1016/j.cell.2006.02.012

A. Ramsay, J. Marshall, and I. Hart, Integrin trafficking and its role in cancer metastasis, Cancer and Metastasis Reviews, vol.282, issue.5, pp.567-578, 2007.
DOI : 10.1007/s10555-007-9078-7

G. Nemerow and P. Stewart, Role of alpha(v) integrins in adenovirus cell entry and gene delivery, Microbiol Mol Biol Rev, vol.63, pp.725-734, 1999.

Y. Ning, T. Buranda, and L. Hudson, Activated Epidermal Growth Factor Receptor Induces Integrin ??2 Internalization via Caveolae/Raft-dependent Endocytic Pathway, Journal of Biological Chemistry, vol.282, issue.9, pp.6380-6387, 2007.
DOI : 10.1074/jbc.M610915200

D. Deyne, P. Neill, A. Resneck, . Wg, . Dmytrenko et al., The vitronectin receptor associates with clathrin-coated membrane domains via the cytoplasmic domain of its beta5 subunit, RJ J Cell Sci, vol.111, pp.2729-2740, 1998.

M. Alam, V. Dixit, H. Kang, . Li, . Zb et al., Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis, Nucleic Acids Research, vol.36, issue.8, pp.2764-2776, 2008.
DOI : 10.1093/nar/gkn115

T. Wickham, P. Mathias, . Cheresh, . Da, . Nemerow et al., Integrins ??v??3 and ??v??5 promote adenovirus internalization but not virus attachment, Cell, vol.73, issue.2, pp.309-319, 1993.
DOI : 10.1016/0092-8674(93)90231-E

B. Adair, J. Xiong, C. Maddock, . Goodman, . Sl et al., Three-dimensional EM structure of the ectodomain of integrin ??V??3 in a complex with fibronectin, The Journal of Cell Biology, vol.172, issue.7, pp.1109-1118, 2005.
DOI : 10.1016/S1047-8477(02)00546-4

D. Boturyn, J. Coll, E. Garanger, M. Favrot, and P. Dumy, Template Assembled Cyclopeptides as Multimeric System for Integrin Targeting and Endocytosis, Journal of the American Chemical Society, vol.126, issue.18, pp.5730-5739, 2004.
DOI : 10.1021/ja049926n

M. Dechantsreiter, E. Planker, B. Matha, E. Lohof, G. Holzemann et al., Integrin Antagonists, Journal of Medicinal Chemistry, vol.42, issue.16, pp.3033-3040, 1999.
DOI : 10.1021/jm970832g

D. Heckmann, A. Meyer, L. Marinelli, G. Zahn, R. Stragies et al., Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the ??5??1 and ??v??3 Integrin Receptor, Angewandte Chemie International Edition, vol.48, issue.19, pp.3571-3574, 2007.
DOI : 10.1002/anie.200700008

C. Kumar, H. Nie, C. Rogers, M. Malkowski, E. Maxwell et al., Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor, J Pharmacol Exp Ther, vol.283, pp.843-853, 1997.

M. Pfaff, K. Tangemann, B. Muller, M. Gurrath, G. Muller et al., Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins, J Biol Chem, vol.269, pp.20233-20238, 1994.

J. Takagi, . Petre, . Bm, T. Walz, and T. Springer, Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling, Cell, vol.110, issue.5, pp.599-511, 2002.
DOI : 10.1016/S0092-8674(02)00935-2

O. Dormond, L. Ponsonnet, M. Hasmim, A. Foletti, and R. , Manganese-induced integrin affinity maturation promotes recruitment of alpha V beta 3 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src, C Thromb Haemost, vol.92, pp.151-161, 2004.

D. Legler, G. Wiedle, F. Ross, and I. , Superactivation of integrin alphavbeta3 by low antagonist concentrations, J Cell Sci, vol.114, pp.1545-1553, 2001.

N. Verdaguer, G. Schoehn, . Ochoa, . Wf, I. Fita et al., Flexibility of the Major Antigenic Loop of Foot-and-Mouth Disease Virus Bound to a Fab Fragment of a Neutralising Antibody: Structure and Neutralisation, Virology, vol.255, issue.2, pp.260-268, 1999.
DOI : 10.1006/viro.1998.9554

J. Bartlett, R. Wilcher, and S. , Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors, Journal of Virology, vol.74, issue.6, pp.2777-2785, 2000.
DOI : 10.1128/JVI.74.6.2777-2785.2000

L. Memmo, P. Mckeown-longo, M. Del-pozo, N. Balasubramanian, . Alderson et al., The alphavbeta5 integrin functions as an endocytic receptor for vitronectin Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization, J Cell Sci Nat Cell Biol, vol.111, issue.7, pp.425-433, 1998.

D. Soumpasis, Theoretical analysis of fluorescence photobleaching recovery experiments, Biophysical Journal, vol.41, issue.1, pp.95-97, 1983.
DOI : 10.1016/S0006-3495(83)84410-5

C. Klein, T. Pillot, J. Chambaz, and B. Drouet, Determination of plasma membrane fluidity with a fluorescent analogue of sphingomyelin by FRAP measurement using a standard confocal microscope, Brain Research Protocols, vol.11, issue.1, pp.46-51, 2003.
DOI : 10.1016/S1385-299X(03)00016-3

M. Roberts, S. Barry, A. Woods, P. Van-der-sluijs, and J. Norman, PDGF-regulated rab4-dependent recycling of ??v??3 integrin from early endosomes is necessary for cell adhesion and spreading, Current Biology, vol.11, issue.18, pp.1392-1402, 2001.
DOI : 10.1016/S0960-9822(01)00442-0