Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV. - Archive ouverte HAL Access content directly
Journal Articles Vaccine Year : 2009

Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV.

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Abstract

Herein, we sought to evaluate the potential of a recombinant Lactococcus lactis strain secreting the Yersinia pseudotuberculosis low-calcium response V (LcrV) antigen for mucosal vaccination against Yersinia infections. We showed that the recombinant strain induced specific systemic and mucosal antibody and cellular immune responses after intranasal immunization and protected mice against both oral and systemic Y. pseudotuberculosis infections. This constitutes the first proof of principle for a novel anti-Yersinia mucosal vaccination strategy using recombinant lactic acid bacteria.
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inserm-00368381 , version 1 (16-03-2009)

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Catherine Daniel, Florent Sebbane, Sabine Poiret, Denise Goudercourt, Joelle Dewulf, et al.. Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV.. Vaccine, 2009, 27 (8), pp.1141-1144. ⟨10.1016/j.vaccine.2008.12.022⟩. ⟨inserm-00368381⟩
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