Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Strategies for reliable exploitation of evolutionary concepts in high throughput biology.

Abstract : The recent availability of the complete genome sequences of a large number of model organisms, together with the immense amount of data being produced by the new high-throughput technologies, means that we can now begin comparative analyses to understand the mechanisms involved in the evolution of the genome and their consequences in the study of biological systems. Phylogenetic approaches provide a unique conceptual framework for performing comparative analyses of all this data, for propagating information between different systems and for predicting or inferring new knowledge. As a result, phylogeny-based inference systems are now playing an increasingly important role in most areas of high throughput genomics, including studies of promoters (phylogenetic footprinting), interactomes (based on the presence and degree of conservation of interacting proteins), and in comparisons of transcriptomes or proteomes (phylogenetic proximity and co-regulation/co-expression). Here we review the recent developments aimed at making automatic, reliable phylogeny-based inference feasible in large-scale projects. We also discuss how evolutionary concepts and phylogeny-based inference strategies are now being exploited in order to understand the evolution and function of biological systems. Such advances will be fundamental for the success of the emerging disciplines of systems biology and synthetic biology, and will have wide-reaching effects in applied fields such as biotechnology, medicine and pharmacology.
Document type :
Journal articles
Complete list of metadata
Contributor : Maité Peney Connect in order to contact the contributor
Submitted on : Friday, March 13, 2009 - 4:41:34 PM
Last modification on : Friday, December 3, 2021 - 9:00:06 AM
Long-term archiving on: : Tuesday, June 8, 2010 - 11:26:13 PM


Publisher files allowed on an open archive


  • HAL Id : inserm-00368022, version 1
  • PUBMED : 19204813



Anthony Levasseur, Pierre Pontarotti, Olivier Poch, Julie D. Thompson. Strategies for reliable exploitation of evolutionary concepts in high throughput biology.. Evolutionary Bioinformatics, Libertas Academica (New Zealand), 2008, 4, pp.121-37. ⟨inserm-00368022⟩



Record views


Files downloads