Skip to Main content Skip to Navigation
Journal articles

AMPK: Lessons from transgenic and knockout animals.

Abstract : AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, has been proposed to function as a fuel gauge to monitor cellular energy status in response to nutritional environmental variations. AMPK system is a regulator of energy balance that, once activated by low energy status, switches on ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis), and switches off ATP-consuming anabolic pathways (such as lipogenesis), both by short-term effect on phosphorylation of regulatory proteins and by long-term effect on gene expression. Numerous observations obtained with pharmacological activators and agents that deplete intracellular ATP have been supportive of AMPK playing a role in the control of energy metabolism but none of these studies have provided conclusive evidence. Relatively recent developments in our understanding of precisely how AMPK complexes might operate to control energy metabolism is due in part to the development of transgenic and knockout mouse models. Although there are inevitable caveats with genetic models, some important findings have emerged. In the present review, we discuss recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway.
Document type :
Journal articles
Complete list of metadatas

Cited literature [100 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00367498
Contributor : Benoit Viollet <>
Submitted on : Wednesday, March 11, 2009 - 2:35:49 PM
Last modification on : Wednesday, September 16, 2020 - 4:54:37 PM
Long-term archiving on: : Tuesday, June 8, 2010 - 11:20:45 PM

Files

review_FBS_animal_models.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : inserm-00367498, version 1
  • PUBMED : 19273052

Collections

Citation

Benoit Viollet, Yoni Athea, Remi Mounier, Bruno Guigas, Elham Zarrinpashneh, et al.. AMPK: Lessons from transgenic and knockout animals.. Frontiers in bioscience : a journal and virtual library, 2009, 14, pp.19-44. ⟨inserm-00367498⟩

Share

Metrics

Record views

799

Files downloads

5997