Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2009

Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.

Abstract

We have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC(50) of 26nM on RAR-beta.

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Pharmaceutical sciences
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Rebecca Deprez-Poulain  : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-00360276

Submitted on : Tuesday, February 10, 2009-6:13:01 PM

Last modification on : Friday, July 17, 2020-10:54:05 AM

Long-term archiving on: Tuesday, June 8, 2010-8:39:59 PM

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inserm-00360276 , version 1 (10-02-2009)

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Julie Charton, Rebecca Deprez-Poulain, Nathalie Hennuyer, Anne Tailleux, Bart Staels, et al.. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.489-92. ⟨10.1016/j.bmcl.2008.11.040⟩. ⟨inserm-00360276⟩

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