Leukotriene signaling in atherosclerosis and ischemia. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cardiovascular Drugs and Therapy Année : 2009

Leukotriene signaling in atherosclerosis and ischemia.

Résumé

INTRODUCTION: The inflammatory process of atherosclerosis is associated with several pathophysiological reactions within the vascular wall. The arachidonic acid released by phospholipase A(2) serves as substrate for the production of a group of lipid mediators known as the leukotrienes, which induce pro-inflammatory signaling through activation of specific BLT and CysLT receptors. DISCUSSION: Leukotriene signaling has been implicated in early lipid retention and foam cell accumulation, as well as in the development of intimal hyperplasia and advanced atherosclerotic lesions. Furthermore, the association of leukotrienes with degradation of extracellular matrix has suggested a role in atherosclerotic plaque rupture. Finally, studies of either myocardial or cerebral ischemia and reperfusion indicate that leukotriene signaling in addition may be involved in the development of ischemic injury. CONCLUSION: Both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested to induce beneficial effects at different stages of the atherosclerosis process.
Fichier principal
Vignette du fichier
Back2009CDT.pdf (264.47 Ko) Télécharger le fichier
inserm-00357698_edited.pdf (1.39 Mo) Télécharger le fichier
Origine : Accord explicite pour ce dépôt
Origine : Accord explicite pour ce dépôt
Loading...

Dates et versions

inserm-00357698 , version 1 (31-01-2009)

Identifiants

Citer

Magnus Bäck. Leukotriene signaling in atherosclerosis and ischemia.. Cardiovascular Drugs and Therapy, 2009, 23 (1), pp.41-8. ⟨10.1007/s10557-008-6140-9⟩. ⟨inserm-00357698⟩
61 Consultations
363 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More