Skip to Main content Skip to Navigation
Journal articles

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.

Abstract : The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a Pro12Ala knockin model, that on chow diet, Ala/Ala mice are leaner, have improved insulin sensitivity and plasma lipid profiles, and have longer lifespans. Gene-environment interactions played a key role as high-fat feeding eliminated the beneficial effects of the Pro12Ala variant on adiposity, plasma lipids, and insulin sensitivity. The underlying molecular mechanisms involve changes in cofactor interaction and adiponectin signaling. Altogether, our results establish the Pro12Ala variant of Ppargamma2 as an important modulator in metabolic control that strongly depends on the metabolic context.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00357415
Contributor : Maité Peney <>
Submitted on : Friday, January 30, 2009 - 12:01:24 PM
Last modification on : Thursday, April 23, 2020 - 2:26:35 PM

Identifiers

Collections

Citation

Sami Heikkinen, Carmen Argmann, Jérôme Feige, Hana Koutnikova, Marie-France Champy, et al.. The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.. Cell Metab, 2009, 9 (1), pp.88-98. ⟨10.1016/j.cmet.2008.11.007⟩. ⟨inserm-00357415⟩

Share

Metrics

Record views

463