B. Bardoni, L. Davidovic, M. Bensaid, and E. Khandjian, The fragile X syndrome: exploring its molecular basis and seeking a treatment, Expert Reviews in Molecular Medicine, vol.8, issue.08, pp.1-16, 2006.
DOI : 10.1017/S1462399406010751

J. Darnell, C. Fraser, O. Mostovetsky, G. Stefani, and T. Jones, Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes, Genes & Development, vol.19, issue.8, pp.903-918, 2005.
DOI : 10.1101/gad.1276805

J. Darnell, K. Jensen, J. P. Brown, V. Warren, and S. , Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function, Cell, vol.107, issue.4, pp.489-499, 2001.
DOI : 10.1016/S0092-8674(01)00566-9

C. Schaeffer, B. Bardoni, J. Mandel, B. Ehresmann, and C. Ehresmann, The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif, The EMBO Journal, vol.20, issue.17, pp.4803-4813, 2001.
DOI : 10.1093/emboj/20.17.4803

M. Castets, C. Schaeffer, E. Bechara, A. Schenck, and E. Khandjian, FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts, Human Molecular Genetics, vol.14, issue.6, pp.835-844, 2005.
DOI : 10.1093/hmg/ddi077

URL : https://hal.archives-ouvertes.fr/hal-00187481

D. De, Y. Otero, L. Severijnen, G. Van-cappellen, M. Schrier et al., Transport of fragile X mental retardation protein via granules in neurites of PC12 cells, Mol Cell Biol, vol.22, pp.8332-8341, 2002.

L. Davidovic, X. Jaglin, A. Lepagnol-bestel, S. Tremblay, and M. Simonneau, The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules, Human Molecular Genetics, vol.16, issue.24, pp.3047-3058, 2007.
DOI : 10.1093/hmg/ddm263

A. Grossman, G. Aldrige, I. Weiler, and W. Greenough, Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond, Journal of Neuroscience, vol.26, issue.27, pp.7151-7155, 2006.
DOI : 10.1523/JNEUROSCI.1790-06.2006

R. Lu, H. Wang, Z. Liang, O. Donnell, W. Li et al., The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development, Proceedings of the National Academy of Sciences, vol.101, issue.42, pp.15201-15206, 2004.
DOI : 10.1073/pnas.0404995101

F. Zalfa, B. Eleuteri, K. Dickson, V. Mecaldo, D. Rubeis et al., A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability, Nature Neuroscience, vol.165, issue.5, pp.578-587, 2007.
DOI : 10.1016/j.schres.2005.07.003

E. Bekay, R. Romero-zerbo, Y. Decara, J. Sanchez-salido, L. et al., Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile???X mental retardation???1-deficient mice, a pathological model for Fragile???X syndrome, European Journal of Neuroscience, vol.191, issue.11, pp.3169-3180, 2007.
DOI : 10.1111/j.1460-9568.2007.05939.x

J. Juarez, M. Manuia, M. Burnett, O. Betancourt, and B. Boivin, Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling, Proceedings of the National Academy of Sciences, vol.105, issue.20, pp.7147-7152, 2008.
DOI : 10.1073/pnas.0709451105

K. Miyashiro, A. Beckel-mitchener, T. Purk, K. Becker, and T. Barret, RNA Cargoes Associating with FMRP Reveal Deficits in Cellular Functioning in Fmr1 Null Mice, Neuron, vol.37, issue.3, pp.417-431, 2003.
DOI : 10.1016/S0896-6273(03)00034-5

S. Adinolfi, C. Bagni, G. Musco, T. Gibson, and L. Mazzarella, Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains, RNA, vol.5, issue.9, pp.1248-1258, 1999.
DOI : 10.1017/S1355838299990647

E. Bechara, L. Davidovic, M. Melko, M. Bensaid, and S. Tremblay, Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure, Nucleic Acids Research, vol.35, issue.1, pp.299-306, 2007.
DOI : 10.1093/nar/gkl1021

URL : https://hal.archives-ouvertes.fr/hal-00172130

C. Brunel and P. Romby, [1] Probing RNA structure and RNA-ligand complexes with chemical probes, Methods Enzymol, vol.318, pp.2-21, 2000.
DOI : 10.1016/S0076-6879(00)18040-1

G. Stefani, C. Fraser, J. Darnell, and R. Darnell, Fragile X Mental Retardation Protein Is Associated with Translating Polyribosomes in Neuronal Cells, Journal of Neuroscience, vol.24, issue.33, pp.9272-9276, 2004.
DOI : 10.1523/JNEUROSCI.2306-04.2004

A. Aschrafi, B. Cunningham, G. Edelman, and P. Vanderklish, The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain, Proceedings of the National Academy of Sciences, vol.102, issue.6, pp.2180-2185, 2005.
DOI : 10.1073/pnas.0409803102

E. Khandjian, M. Huot, S. Tremblay, L. Davidovic, and R. Mazroui, Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles, Proceedings of the National Academy of Sciences, vol.101, issue.36, pp.13357-13362, 2004.
DOI : 10.1073/pnas.0405398101

F. Corbin, M. Bouillon, A. Fortin, S. Morin, and F. Rousseau, The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes, Human Molecular Genetics, vol.6, issue.9, pp.1465-1472, 1997.
DOI : 10.1093/hmg/6.9.1465

Y. Feng, D. Absher, D. Eberhart, Y. H. Brown, and V. , FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association, Molecular Cell, vol.1, issue.1, pp.109-118, 1997.
DOI : 10.1016/S1097-2765(00)80012-X

P. Martin, O. Albaghi, M. Poggi, K. Boulukos, and P. Pognonec, Development of a new bicistronic retroviral vector with strong IRES activity, BMC Biotechnology, vol.6, issue.1, p.4, 2006.
DOI : 10.1186/1472-6750-6-4

URL : https://hal.archives-ouvertes.fr/inserm-00089235

J. Darnell, O. Mostovetsky, and R. Darnell, FMRP RNA targets: identification and validation, Genes, Brain and Behavior, vol.14, issue.6, pp.341-349, 2005.
DOI : 10.1002/(SICI)1096-8628(19990528)84:3<268::AID-AJMG20>3.0.CO;2-#

E. Khandjian, E. Bechara, L. Davidovic, and B. Bardoni, Fragile X Mental Retardation Protein: Many Partners and Multiple Targets for a Promiscuous Function, Current Genomics, vol.6, issue.7, pp.515-522, 2005.
DOI : 10.2174/138920205775067701

P. Todd, K. Mack, and J. Malter, The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95, Proceedings of the National Academy of Sciences, vol.100, issue.24, pp.14374-14378, 2003.
DOI : 10.1073/pnas.2336265100

A. Iacoangeli, T. Rozhdestvensky, N. Dolzhanskaya, B. Tournier, and J. Schutt, On BC1 RNA and the fragile X mental retardation protein, Proceedings of the National Academy of Sciences, vol.105, issue.2, pp.734-739, 2008.
DOI : 10.1073/pnas.0710991105

B. Laggerbauer, D. Ostareck, E. Keidel, A. Ostareck-lederer, and U. Fischer, Evidence that fragile X mental retardation protein is a negative regulator of translation, Human Molecular Genetics, vol.10, issue.4, pp.329-338, 2001.
DOI : 10.1093/hmg/10.4.329

S. Vasudevan and J. Steitz, AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2, Cell, vol.128, issue.6, pp.1105-1118, 2007.
DOI : 10.1016/j.cell.2007.01.038

Y. Zhang, D. Friedman, Z. Wang, E. Woodruff, . Iii et al., Protein Expression Profiling of the Drosophila Fragile X Mutant Brain Reveals Up-regulation of Monoamine Synthesis, Molecular & Cellular Proteomics, vol.4, issue.3, pp.278-290, 2005.
DOI : 10.1074/mcp.M400174-MCP200

Y. Zhang, H. Matthies, J. Mancuso, H. Andrews, and E. Woodruff, The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis, Developmental Biology, vol.270, issue.2, pp.290-307, 2004.
DOI : 10.1016/j.ydbio.2004.02.010

J. Gingrinch, Oxidative stress is the new stress, Nature, vol.11, pp.1281-1282, 2005.

C. Cirelli, Sleep disruption, oxidative stress, and aging: New insights from fruit flies, Proceedings of the National Academy of Sciences, vol.103, issue.38, pp.13901-13902, 2006.
DOI : 10.1073/pnas.0606652103

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599884

X. Ming, T. Stein, M. Brimacombe, W. Johnson, and G. Lambert, Increased excretion of a lipid peroxidation biomarker in autism, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.73, issue.5, pp.379-384, 2006.
DOI : 10.1016/j.plefa.2005.06.002

R. Hagerman and A. Cronister, Fragile X syndrome, Current Problems in Pediatrics, vol.17, issue.11, 1996.
DOI : 10.1016/0045-9380(87)90011-9

URL : https://hal.archives-ouvertes.fr/hal-01104162

D. De, Y. Otero, Y. Romero-zerbo, R. Bekay, J. Decara et al., ) a-Tocopherol protects againsts oxidative stress in the Fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency. Neuropsychopharmacology. E-pub ahead of print, p.152, 2008.

S. Kim, J. Markham, I. Weiler, and W. Greenough, Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.4429-4434, 2008.
DOI : 10.1073/pnas.0800257105

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262