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. Fig, Mean cell fluorescence intensities (MFI) as a function of the concentration of cell penetrating complexes for each MCa analog Indicated concentrations are for Strep-Cy5 (10 nM to 2.5 µM) The ratio MCa analog / Strep-Cy5 was 4/1. Data were fitted by a sigmoid equation of the type MFI = MFI max / (1 + exp(-(x-PC 50 )/b)) where MFI max = 180 ± 6 a

E. Abu and =. , MCa b -Abu E12A), and halfpenetration concentration values PC 50 = 669 ± 27 nM (MCa b ), 910 ± 51 nM (MCa b -Abu) and 1042 ± 89 nM (MCa b -Abu E12A). a.u.: arbitrary units. The MFI values are obtained from a fit of the FACS histograms (n=10,000 events in each case), pp.301-339