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Dual and beneficial roles of macrophages during skeletal muscle regeneration.

Abstract : Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.
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Contributor : Benedicte Chazaud <>
Submitted on : Monday, January 19, 2009 - 12:15:55 PM
Last modification on : Monday, October 12, 2020 - 3:34:02 PM



Bénédicte Chazaud, Madly Brigitte, Houda Yacoub-Youssef, Ludovic Arnold, Romain Gherardi, et al.. Dual and beneficial roles of macrophages during skeletal muscle regeneration.. Exercise and Sport Sciences Reviews, American College of Sports Medicine, 2009, 37 (1), pp.18-22. ⟨10.1097/JES.0b013e318190ebdb⟩. ⟨inserm-00354230⟩



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