Skip to Main content Skip to Navigation
Journal articles

[Early embryogenesis in mammals: stem cells and first commitments steps.]

Abstract : In mammals, embryonic and extraembryonic cell lineages segregate during the first steps of cell differentiation in the preimplantation embryo. Indeed, mammal embryos contain very low energy stocks and thus get ready for implantation very early to be able to absorbe nutrients from the mother, first through the yolk sac and then through the placenta. These first steps involve classical genetic and morphogenetic processes as well as specific mechanisms of early embryo development such as epigenetic reprogramming and maintenance of pluripotent cells. Embryo analysis led to the isolation of embryonic stem (ES) cells, granted by the 2007 Nobel prize of Medicine (to M. Evans, M. Capecchi and O. Smithies) and which offer strong hopes for cell therapy. double dagger.
Document type :
Journal articles
Complete list of metadatas

Cited literature [43 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00352615
Contributor : Claire Chazaud <>
Submitted on : Tuesday, January 13, 2009 - 2:09:04 PM
Last modification on : Wednesday, March 4, 2020 - 11:26:39 AM
Long-term archiving on: : Thursday, October 11, 2012 - 3:56:34 PM

File

Chazaud_Med_Sci.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : inserm-00352615, version 1
  • PUBMED : 19116112

Collections

Citation

Claire Chazaud. [Early embryogenesis in mammals: stem cells and first commitments steps.]. médecine/sciences, EDP Sciences, 2008, 24 (12), pp.1043-8. ⟨inserm-00352615⟩

Share

Metrics

Record views

237

Files downloads

225