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Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.

Abstract : CD160 has been initially identified as a GPI-anchored MHC-class I activating receptor mainly expressed on peripheral blood NK cells. Herein, we report the identification of three additional CD160-related mRNAs generated through alternative splicings of the CD160 gene, among which one encoded a putative CD160 transmembrane isoform (CD160-TM). We first establish that CD160-TM surface expression is highly restricted to NK cells and is activation-dependent. Additionally, we provide evidence that CD160-TM represents a novel activating receptor, as assessed by the increased CD107a NK cell surface mobilization observed upon its engagement. Finally, we demonstrate that the CD160-TM cytoplasmic tail is by itself sufficient to mediate the recruitment of Erk1/2 signaling pathway, and that the initiation of this activation process is dependent on the Src-family kinase p56(lck). The identification of CD160-TM therefore provides new possibilities regarding the role of CD160 isoforms in the regulation of NK cell functions.
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https://www.hal.inserm.fr/inserm-00352331
Contributor : Georges Guellaen <>
Submitted on : Monday, January 4, 2010 - 10:46:12 AM
Last modification on : Wednesday, September 4, 2019 - 1:52:09 PM
Long-term archiving on: : Tuesday, June 8, 2010 - 5:45:37 PM

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  • HAL Id : inserm-00352331, version 1
  • PUBMED : 19109136

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Jérôme Giustiniani, Armand Bensussan, Anne Marie-Cardine. Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (1), pp.63-71. ⟨inserm-00352331⟩

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