J. Gonzalez-de-aguilar, A. Echaniz-laguna, and A. Fergani, Amyotrophic lateral sclerosis: all roads lead to Rome, Journal of Neurochemistry, vol.4, issue.5, pp.1153-60, 2007.
DOI : 10.1038/ng1001-160

S. Boillee, V. Velde, C. , and C. Dw, ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors, Neuron, vol.52, issue.1, pp.39-59, 2006.
DOI : 10.1016/j.neuron.2006.09.018

D. Rosen, T. Siddique, and D. Patterson, Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature, vol.362, issue.6415, pp.59-62, 1993.
DOI : 10.1038/362059a0

L. Fischer, D. Culver, and P. Tennant, Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man, Experimental Neurology, vol.185, issue.2, pp.232-272, 2004.
DOI : 10.1016/j.expneurol.2003.10.004

D. Frey, C. Schneider, and L. Xu, Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases, J Neurosci, vol.20, pp.2534-2576, 2000.

S. Pun, A. Santos, and S. Saxena, Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF, Nature Neuroscience, vol.11, issue.3, pp.408-427, 2006.
DOI : 10.1038/nn1653

C. Guegan and S. Przedborski, Programmed cell death in amyotrophic lateral sclerosis, Journal of Clinical Investigation, vol.111, issue.2, pp.153-61, 2003.
DOI : 10.1172/JCI200317610

C. Rouaux, I. Panteleeva, and F. Rene, Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model, Journal of Neuroscience, vol.27, issue.21, pp.5535-5580, 2007.
DOI : 10.1523/JNEUROSCI.1139-07.2007

T. Gould, R. Buss, and S. Vinsant, Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS, Journal of Neuroscience, vol.26, issue.34, pp.8774-86, 2006.
DOI : 10.1523/JNEUROSCI.2315-06.2006

M. Dewil, V. Cruz, . Van-den, and L. Bosch, Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death, Neurobiology of Disease, vol.26, issue.2, pp.332-373, 2007.
DOI : 10.1016/j.nbd.2006.12.023

A. Pramatarova, J. Laganiere, and J. Roussel, Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment, J Neurosc, vol.21, pp.3369-74, 2001.

M. Lino, C. Schneider, and P. Caroni, Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease, J Neurosci, vol.22, pp.4825-4857, 2002.

S. Boillee, K. Yamanaka, and C. Lobsiger, Onset and progression in inherited, ALS Dupuis & Loeffler, vol.11, issue.15

A. Clement, M. Nguyen, and E. Roberts, Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice, Science, vol.302, issue.5642, pp.1389-92, 2003.
DOI : 10.1126/science.1086071

B. Pettmann, C. Raoul, and G. Haase, Mort des motoneurones dans la SLA : Suicide ou meurtre???, m??decine/sciences, vol.22, issue.11, pp.923-928, 2006.
DOI : 10.1051/medsci/20062211923

S. Boillée and C. Lobsiger, Les cellules gliales, m??decine/sciences, vol.24, issue.2, pp.124-130, 2008.
DOI : 10.1051/medsci/2008242124

M. Pehar, P. Cassina, and M. Vargas, Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis, Journal of Neurochemistry, vol.269, issue.2, pp.464-73, 2004.
DOI : 10.1006/dbio.1994.1131

M. Vargas, M. Pehar, and P. Cassina, Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis, Journal of Neurochemistry, vol.538, issue.3, pp.687-96, 2006.
DOI : 10.1111/j.1471-4159.2006.03742.x

M. Nagai, D. Re, and T. Nagata, Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons, Nature Neuroscience, vol.67, issue.5, pp.615-637, 2007.
DOI : 10.1016/S0092-8674(00)80323-2

D. Giorgio, F. Carrasco, M. Siao, and M. , Non???cell autonomous effect of glia on motor neurons in an embryonic stem cell???based ALS model, Nature Neuroscience, vol.252, issue.5, pp.608-622, 2007.
DOI : 10.1038/nn1876

K. Yamanaka, S. Chun, and S. Boillee, Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis, Nature Neuroscience, vol.96, issue.3, 2008.
DOI : 10.1038/nn2047

D. Beers, J. Henkel, and Q. Xiao, Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences, vol.103, issue.43, pp.16021-16027, 2006.
DOI : 10.1073/pnas.0607423103
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613228

L. Dupuis, J. Gonzalez-de-aguilar, and F. Di-scala, Nogo Provides a Molecular Marker for Diagnosis of Amyotrophic Lateral Sclerosis, Neurobiology of Disease, vol.10, issue.3, pp.358-65, 2002.
DOI : 10.1006/nbdi.2002.0522

N. Jokic, J. Gonzalez-de-aguilar, and P. Pradat, Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity, Annals of Neurology, vol.23, issue.4, pp.553-559, 2005.
DOI : 10.1002/ana.20420

P. Pradat, G. Bruneteau, and J. Gonzalez-de-aguilar, Muscle Nogo-a expression is a prognostic marker in lower motor neuron syndromes, Annals of Neurology, vol.66, issue.1, pp.15-20, 2007.
DOI : 10.1002/ana.21122

N. Jokic, J. Gonzalez-de-aguilar, and L. Dimou, The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model, EMBO reports, vol.23, issue.11, pp.1162-1169, 2006.
DOI : 10.1016/j.nbd.2005.06.005

G. Dobrowolny, C. Giacinti, and L. Pelosi, Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model, The Journal of Cell Biology, vol.105, issue.2, pp.193-202, 2005.
DOI : 10.1016/S0896-6273(00)80086-0

T. Miller, S. Kim, and K. Yamanaka, Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis, Proceedings of the National Academy of Sciences, vol.103, issue.51, pp.19546-51, 2006.
DOI : 10.1073/pnas.0609411103

C. Towne, C. Raoul, and B. Schneider, Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice, Molecular Therapy, vol.16, issue.6, 2008.
DOI : 10.1038/mt.2008.73

L. Dupuis, H. Oudart, and F. Rene, Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: Benefit of a high-energy diet in a transgenic mouse model, Proceedings of the National Academy of Sciences, vol.101, issue.30
DOI : 10.1073/pnas.0402026101

A. Fergani, H. Oudart, and J. Gonzalez-de-aguilar, Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis, The Journal of Lipid Research, vol.48, issue.7, pp.1571-80, 2007.
DOI : 10.1194/jlr.M700017-JLR200
URL : https://hal.archives-ouvertes.fr/hal-00160852

M. Mattson, R. Cutler, and S. Camandola, Energy Intake and Amyotrophic Lateral Sclerosis, NeuroMolecular Medicine, vol.9, issue.1, pp.17-20, 2007.
DOI : 10.1385/NMM:9:1:17

N. Maswood, J. Young, and E. Tilmont, Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease, Proceedings of the National Academy of Sciences, vol.101, issue.52, pp.18171-18177, 2004.
DOI : 10.1073/pnas.0405831102

S. Rasouri, M. Lagouge, and J. Auwerx, PGC-1: un axe neuroprotecteur? Med Sci (Paris), pp.840-844, 2007.

J. Desport, P. Preux, and L. Magy, Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis, Am J Clin Nutr, vol.74, pp.328-362, 2001.

J. Desport, P. Preux, and T. Truong, Nutritional status is a prognostic factor for survival in ALS patients, Neurology, vol.53, issue.5, pp.1059-63, 1999.
DOI : 10.1212/WNL.53.5.1059
URL : https://hal.archives-ouvertes.fr/hal-01083608

J. Desport, F. Torny, and M. Lacoste, Hypermetabolism in ALS: Correlations with Clinical and Paraclinical Parameters, Neurodegenerative Diseases, vol.2, issue.3-4, pp.202-209, 2005.
DOI : 10.1159/000089626

L. Dupuis, P. Corcia, and A. Fergani, Dyslipidemia is a protective factor in amyotrophic lateral sclerosis, Neurology, vol.70, issue.13, 2008.
DOI : 10.1212/01.wnl.0000285080.70324.27

M. Benatar, Lost in translation: Treatment trials in the SOD1 mouse and in human ALS, Neurobiology of Disease, vol.26, issue.1, pp.1-13, 2007.
DOI : 10.1016/j.nbd.2006.12.015

L. Dupuis, D. Scala, F. Rene, and F. , Up-regulation of mitochondrial uncoupling protein 3