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Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

Abstract : The human CD1a-d proteins are plasma membrane molecules involved in the presentation of lipid Ags to T cells. In contrast, CD1e is an intracellular protein present in a soluble form in late endosomes or lysosomes and is essential for the processing of complex glycolipid Ags such as hexamannosylated phosphatidyl-myo-inositol, PIM(6). CD1e is formed by the association of beta(2)-microglobulin with an alpha-chain encoded by a polymorphic gene. We report here that one variant of CD1e with a proline at position 194, encoded by allele 4, does not assist PIM(6) presentation to CD1b-restricted specific T cells. The immunological incompetence of this CD1e variant is mainly due to inefficient assembly and poor transport of this molecule to late endosomal compartments. Although the allele 4 of CD1E is not frequent in the population, our findings suggest that homozygous individuals might display an altered immune response to complex glycolipid Ags.
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Contributor : Maité Peney <>
Submitted on : Tuesday, February 3, 2009 - 10:33:41 AM
Last modification on : Tuesday, March 23, 2021 - 3:30:03 AM


  • HAL Id : inserm-00351035, version 1
  • PUBMED : 18325888


Sylvie Tourne, Blandine Maitre, Anthony Collmann, Emilie Layre, Sabrina Mariotti, et al.. Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (6), pp.3642-6. ⟨inserm-00351035⟩



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