Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

Sylvie Tourne; Blandine Maitre; Anthony Collmann; Emilie Layre; Sabrina Mariotti; François Signorino-Gelo; Caroline Loch; Jean Salamero; Martine Gilleron; Catherine Angénieux; Jean-Pierre Cazenave; Lucia Mori; Daniel Hanau; Germain Puzo; Gennaro de Libero; Henri de la Salle

Journal articles

Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

Sylvie Tourne ^{1, 2} Blandine Maitre ^{1, 2, 3} Anthony Collmann ⁴ Emilie Layre ⁵ Sabrina Mariotti ⁴ François Signorino-Gelo ^{1, 2, 6} Caroline Loch ⁷ Jean Salamero ⁸ Martine Gilleron ⁵ Catherine Angénieux ^{1, 2} Jean-Pierre Cazenave ^{2, 3, 6} Lucia Mori ⁴ Daniel Hanau ^{1, 6} Germain Puzo ⁵ Gennaro de Libero ⁴ Henri de la Salle ^{1, 2}

1 Biologie des Cellules Dendritiques Humaines

2 EFS

3 Biologie et pharmacologie de l'hémostase et de la thrombose

4 Experimental Immunology

5 IPBS - Institut de pharmacologie et de biologie structurale

6 Biologie des cellules dendritiques humaines

7 IGBMC - Institut de génétique et biologie moléculaire et cellulaire

8 CDC - Compartimentation et dynamique cellulaires

Abstract : The human CD1a-d proteins are plasma membrane molecules involved in the presentation of lipid Ags to T cells. In contrast, CD1e is an intracellular protein present in a soluble form in late endosomes or lysosomes and is essential for the processing of complex glycolipid Ags such as hexamannosylated phosphatidyl-myo-inositol, PIM(6). CD1e is formed by the association of beta(2)-microglobulin with an alpha-chain encoded by a polymorphic gene. We report here that one variant of CD1e with a proline at position 194, encoded by allele 4, does not assist PIM(6) presentation to CD1b-restricted specific T cells. The immunological incompetence of this CD1e variant is mainly due to inefficient assembly and poor transport of this molecule to late endosomal compartments. Although the allele 4 of CD1E is not frequent in the population, our findings suggest that homozygous individuals might display an altered immune response to complex glycolipid Ags.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

Complete list of metadatas

https://www.hal.inserm.fr/inserm-00351035
Contributor : Maité Peney <>
Submitted on : Tuesday, February 3, 2009 - 10:33:41 AM
Last modification on : Tuesday, October 20, 2020 - 8:52:45 AM

Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

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Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

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