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PtdIns5P regulation through evolution: roles in membrane trafficking?

Abstract : Phosphoinositides are lipid second messengers that are essential for many cellular processes, including signal transduction and cell compartmentalization. Among them, phosphatidylinositol 5-phosphate (PtdIns5P) is the least characterized, although several proteins involved in its regulation are implicated in human diseases. We studied the distribution of 32 PtdIns5P-metabolizing proteins in 39 eukaryotic genomes. Phylogenetic profiles identify four groups of co-evolving proteins, confirming known protein complexes and revealing new ones. The complexes comprise a phosphatase, a kinase and a regulator; this indicates that physical interactions between the three partners are necessary for the acute spatial regulation of PtdIns5P turnover. By examining PtdIns5P metabolism in this new perspective, we propose a role for PtdIns5P in membrane trafficking from late endosomal compartments to the plasma membrane.
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https://www.hal.inserm.fr/inserm-00350907
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Submitted on : Wednesday, January 7, 2009 - 5:33:16 PM
Last modification on : Thursday, April 23, 2020 - 2:26:26 PM

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Odile Lecompte, Olivier Poch, Jocelyn Laporte. PtdIns5P regulation through evolution: roles in membrane trafficking?. Trends in Biochemical Sciences, Elsevier, 2008, 33 (10), pp.453-60. ⟨10.1016/j.tibs.2008.07.002⟩. ⟨inserm-00350907⟩

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