Skip to Main content Skip to Navigation
Journal articles

PtdIns5P regulation through evolution: roles in membrane trafficking?

Abstract : Phosphoinositides are lipid second messengers that are essential for many cellular processes, including signal transduction and cell compartmentalization. Among them, phosphatidylinositol 5-phosphate (PtdIns5P) is the least characterized, although several proteins involved in its regulation are implicated in human diseases. We studied the distribution of 32 PtdIns5P-metabolizing proteins in 39 eukaryotic genomes. Phylogenetic profiles identify four groups of co-evolving proteins, confirming known protein complexes and revealing new ones. The complexes comprise a phosphatase, a kinase and a regulator; this indicates that physical interactions between the three partners are necessary for the acute spatial regulation of PtdIns5P turnover. By examining PtdIns5P metabolism in this new perspective, we propose a role for PtdIns5P in membrane trafficking from late endosomal compartments to the plasma membrane.
Document type :
Journal articles
Complete list of metadata
Contributor : Maité Peney Connect in order to contact the contributor
Submitted on : Wednesday, January 7, 2009 - 5:33:16 PM
Last modification on : Monday, March 14, 2022 - 12:26:02 PM

Links full text



Odile Lecompte, Olivier Poch, Jocelyn Laporte. PtdIns5P regulation through evolution: roles in membrane trafficking?. Trends in Biochemical Sciences, Elsevier, 2008, 33 (10), pp.453-60. ⟨10.1016/j.tibs.2008.07.002⟩. ⟨inserm-00350907⟩



Record views