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Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle.

Abstract : This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
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Journal articles
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https://www.hal.inserm.fr/inserm-00350823
Contributor : Maité Peney <>
Submitted on : Wednesday, January 7, 2009 - 4:29:02 PM
Last modification on : Thursday, April 23, 2020 - 2:26:26 PM

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  • HAL Id : inserm-00350823, version 1
  • PUBMED : 18979628

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Elena Roza Motrescu, Marie-Christine Rio. Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle.. Biological Chemistry, De Gruyter, 2008, 389 (8), pp.1037-41. ⟨inserm-00350823⟩

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