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Ability of family members to predict patient's consent to critical care research.

Magali Ciroldi 1 Alain Cariou 1, 2 Christophe Adrie 1, 3 Djilali Annane 4, 1 Vincent Castelain 1, 5 Yves Cohen 1, 6 Arnaud Delahaye 1 Luc Marie Joly 1 Richard Galliot 1, 7 Maïté Garrouste-Orgeas 1, 8 Laurent Papazian 9 Fabrice Michel 1 Nancy Kenstish Barnes 1 Benoit Schlemmer 1 Frédéric Pochard 1 Elie Azoulay 1
1 Service de réanimation médicale
2 General ICU
3 EA 2511 - Mucoviscidose et bronchopathies chroniques : biopathologie et phénotypes cliniques
4 Hôpital Raymond Poincaré [AP-HP]
5 Hôpital de Strasbourg
6 Service de Réanimation Médico-Chirurgicale [Avicenne]
7 Hôpital de Pontoise
8 Medical-Surgical ICU
9 Hôpital Sainte-Marguerite
Abstract : OBJECTIVE: A European Union Directive provides for the designation of a surrogate who can consent to or refuse inclusion of an incapacitated patient in research studies. The accuracy with which surrogates consent to research on behalf of patients has not been evaluated in the intensive care unit (ICU). METHODS: A prospective multicenter study was conducted in ten ICUs of the French Famirea study group between July and October 2004. Two hypothetical studies were simultaneously submitted to the patient, surrogate, and physician at the time that the patient was discharged to a ward. One study involved minimal risk and the other greater-than-minimal risk to the patients. RESULTS: With the minimal risk study there was patient-surrogate discrepancy in 32% of cases and patient-physician discrepancy in 25%. Corresponding figures with the greater-than-minimal risk study were 42% and 46%. None of the collected variables differed significantly between cases with and without patient-surrogate discrepancy. CONCLUSIONS: Family members designated to serve as surrogate decision makers may fail to accurately consent to research for critically ill patients in one-third to nearly one-half of cases.
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https://www.hal.inserm.fr/inserm-00349136
Contributor : Aurélien Vesin <>
Submitted on : Tuesday, December 23, 2008 - 4:16:32 PM
Last modification on : Wednesday, August 19, 2020 - 11:21:19 AM

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UNIV-PARIS5 | UNIV-PARIS7 | UNIV-PARIS13 | USPC

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Magali Ciroldi, Alain Cariou, Christophe Adrie, Djilali Annane, Vincent Castelain, et al.. Ability of family members to predict patient's consent to critical care research.. Intensive Care Medicine, Springer Verlag, 2007, 33 (5), pp.807-13. ⟨10.1007/s00134-007-0582-6⟩. ⟨inserm-00349136⟩

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