Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Applied Physiology Année : 2008

Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury.

Résumé

A high respiratory rate associated with the use of small tidal volumes, recommended for acute lung injury (ALI), shortens time for gas diffusion in the alveoli. This may decrease CO(2) elimination. We hypothesized that a postinspiratory pause could enhance CO(2) elimination and reduce Pa(CO(2)) by reducing dead space in ALI. In 15 mechanically ventilated patients with ALI and hypercapnia, a 20% postinspiratory pause (Tp20) was applied during a period of 30 min between two ventilation periods without postinspiratory pause (Tp0). Other parameters were kept unchanged. The single breath test for CO(2) was recorded every 5 min to measure tidal CO(2) elimination (VtCO(2)), airway dead space (V(Daw)), and slope of the alveolar plateau. Pa(O(2)), Pa(CO(2)), and physiological and alveolar dead space (V(Dphys), V(Dalv)) were determined at the end of each 30-min period. The postinspiratory pause, 0.7 +/- 0.2 s, induced on average <0.5 cmH(2)O of intrinsic positive end-expiratory pressure (PEEP). During Tp20, VtCO(2) increased immediately by 28 +/- 10% (14 +/- 5 ml per breath compared with 11 +/- 4 for Tp0) and then decreased without reaching the initial value within 30 min. The addition of a postinspiratory pause significantly decreased V(Daw) by 14% and V(Dphys) by 11% with no change in V(Dalv). During Tp20, the slope of the alveolar plateau initially fell to 65 +/- 10% of baseline value and continued to decrease. Tp20 induced a 10 +/- 3% decrease in Pa(CO(2)) at 30 min (from 55 +/- 10 to 49 +/- 9 mmHg, P < 0.001) with no significant variation in Pa(O(2)). Postinspiratory pause has a significant influence on CO(2) elimination when small tidal volumes are used during mechanical ventilation for ALI.
Fichier principal
Vignette du fichier
Devaquet_Tp_resubmitted.pdf (356.47 Ko) Télécharger le fichier
inserm-00348824_edited.pdf (357.48 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-00348824 , version 1 (29-09-2010)

Identifiants

Citer

Jérôme Devaquet, Björn Jonson, Lisbet Niklason, Anne-Gaëlle Si Larbi, Leif Uttman, et al.. Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury.. Journal of Applied Physiology, 2008, 105 (6), pp.1944-9. ⟨10.1152/japplphysiol.90682.2008⟩. ⟨inserm-00348824⟩

Collections

INSERM IMRB UPEC
86 Consultations
831 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More