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Synthesis and pH-dependent micellization of diblock copolymer mixtures.

Abstract : This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(epsilon-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL(34)-b-PEO(114) and PCL(32)-b-P2VP(52) diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks-thus on the composition, shape, size and surface properties of the micelles-was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test.
keyword : Micelle Copolymer
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Contributor : Laurent Lemaire <>
Submitted on : Wednesday, September 7, 2011 - 8:33:25 AM
Last modification on : Tuesday, May 7, 2019 - 6:30:07 PM
Long-term archiving on: : Tuesday, November 13, 2012 - 10:00:23 AM


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Kathy van Butsele, Pierre Sibret, Charles-André Fustin, Gohy Jean-François, Catherine Passirani, et al.. Synthesis and pH-dependent micellization of diblock copolymer mixtures.. Journal of Colloid and Interface Science, Elsevier, 2009, 329 (2), pp.235-43. ⟨10.1016/j.jcis.2008.09.080⟩. ⟨inserm-00343572⟩



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